COX4_STRCO
ID COX4_STRCO Reviewed; 132 AA.
AC Q9X812;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome aa3 subunit 4;
DE AltName: Full=Cytochrome c oxidase polypeptide IV;
GN Name=ctaF; OrderedLocusNames=SCO2154; ORFNames=SC6G10.27c;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC oxidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC family. {ECO:0000305}.
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DR EMBL; AL939111; CAB39881.1; -; Genomic_DNA.
DR PIR; T35536; T35536.
DR RefSeq; NP_626410.1; NC_003888.3.
DR RefSeq; WP_003976661.1; NZ_VNID01000001.1.
DR AlphaFoldDB; Q9X812; -.
DR SMR; Q9X812; -.
DR STRING; 100226.SCO2154; -.
DR TCDB; 3.D.4.4.5; the proton-translocating cytochrome oxidase (cox) superfamily.
DR GeneID; 1097588; -.
DR KEGG; sco:SCO2154; -.
DR PATRIC; fig|100226.15.peg.2189; -.
DR eggNOG; ENOG5031SSV; Bacteria.
DR HOGENOM; CLU_145919_0_0_11; -.
DR InParanoid; Q9X812; -.
DR OMA; GTYFRFV; -.
DR PhylomeDB; Q9X812; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR Pfam; PF12270; Cyt_c_ox_IV; 1.
DR PIRSF; PIRSF017385; CtaF; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..132
FT /note="Probable cytochrome c oxidase polypeptide 4"
FT /id="PRO_0000220022"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..127
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 132 AA; 14581 MW; 12A6AFCFC3376438 CRC64;
MKIQGKMFIW LSVFILAVAV VYGYWSKEPA GTTALFLAFG LAIMIGFYLA FTARRVDAGA
QDDMEADVAD EAGEVGFFSP HSWQPLSLAV GGALAFLGIA VGWWVMYFSA PILMVGLFGW
VFEYYRGENR TQ
