ID   COX5A_NOTPR             Reviewed;         154 AA.
AC   B0VYY5;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   23-FEB-2022, entry version 41.
DE   RecName: Full=Cytochrome c oxidase subunit 5A, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase polypeptide Va;
DE   Flags: Precursor;
GN   Name=COX5A;
OS   Notamacropus parma (Parma wallaby) (Macropus parma).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=413582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18197981; DOI=10.1186/1471-2148-8-8;
RA   Uddin M., Opazo J.C., Wildman D.E., Sherwood C.C., Hof P.R., Goodman M.,
RA   Grossman L.I.;
RT   "Molecular evolution of the cytochrome c oxidase subunit 5A gene in
RT   primates.";
RL   BMC Evol. Biol. 8:8-8(2008).
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00427}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:P00427}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC       COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC       are encoded in the nuclear genome. The complex exists as a monomer or a
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC       Interacts with AFG1L (By similarity). Interacts with RAB5IF (By
CC       similarity). {ECO:0000250|UniProtKB:P00426,
CC       ECO:0000250|UniProtKB:P20674}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P00426}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P00426}; Matrix side
CC       {ECO:0000250|UniProtKB:P00426}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 5A family.
CC       {ECO:0000305}.
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DR   EMBL; DQ987252; ABK92299.1; -; mRNA.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR   CDD; cd00923; Cyt_c_Oxidase_Va; 1.
DR   Gene3D; 1.25.40.40; -; 1.
DR   InterPro; IPR003204; Cyt_c_oxidase_su5A/6.
DR   InterPro; IPR036545; Cyt_c_oxidase_su5A/6_sf.
DR   PANTHER; PTHR14200; PTHR14200; 1.
DR   Pfam; PF02284; COX5A; 1.
DR   SUPFAM; SSF48479; SSF48479; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Heme; Iron; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Phosphoprotein; Transit peptide.
FT   TRANSIT         1..45
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:P00426"
FT   CHAIN           46..154
FT                   /note="Cytochrome c oxidase subunit 5A, mitochondrial"
FT                   /id="PRO_0000355983"
FT   MOD_RES         91
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P12787"
FT   MOD_RES         117
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P12787"
FT   MOD_RES         145
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P20674"
SQ   SEQUENCE   154 AA;  17110 MW;  EC6BBAAA73F4D941 CRC64;
     MLAAALRRCX ASVRVLLPKP GAAAPSSWSS SAFRATAAIQ SVRCYSHGSH ETDEEFDARW
     VTYFSKPDLD AWELRKGMNT LVGYDLVPEP KIIDAALRAC RRLDDFASAV RILEVVKDKA
     GPHKEIYPYI IQELRPTLDE LGISTPEELG LDKP