COX6A_CAEEL
ID COX6A_CAEEL Reviewed; 128 AA.
AC Q20779;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Cytochrome c oxidase subunit 6A, mitochondrial {ECO:0000305};
DE AltName: Full=Cytochrome c oxidase polypeptide VIa {ECO:0000305};
DE Flags: Precursor;
GN Name=cox-6A {ECO:0000312|WormBase:F54D8.2};
GN Synonyms=tag-174 {ECO:0000312|WormBase:F54D8.2};
GN ORFNames=F54D8.2 {ECO:0000312|WormBase:F54D8.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules unsing 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P32799}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P32799}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of a catalytic core of 3 subunits and
CC several supernumerary subunits. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1
CC complex, complex III, CIII). {ECO:0000250|UniProtKB:P32799}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P32799}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P32799}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 6A family.
CC {ECO:0000305}.
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DR EMBL; BX284603; CCD67407.1; -; Genomic_DNA.
DR PIR; E88449; E88449.
DR RefSeq; NP_498082.1; NM_065681.5.
DR AlphaFoldDB; Q20779; -.
DR SMR; Q20779; -.
DR BioGRID; 40925; 57.
DR IntAct; Q20779; 1.
DR MINT; Q20779; -.
DR STRING; 6239.F54D8.2.1; -.
DR EPD; Q20779; -.
DR PaxDb; Q20779; -.
DR PeptideAtlas; Q20779; -.
DR EnsemblMetazoa; F54D8.2.1; F54D8.2.1; WBGene00006519.
DR EnsemblMetazoa; F54D8.2.2; F54D8.2.2; WBGene00006519.
DR EnsemblMetazoa; F54D8.2.3; F54D8.2.3; WBGene00006519.
DR EnsemblMetazoa; F54D8.2.4; F54D8.2.4; WBGene00006519.
DR GeneID; 175693; -.
DR KEGG; cel:CELE_F54D8.2; -.
DR UCSC; F54D8.2.1; c. elegans.
DR CTD; 175693; -.
DR WormBase; F54D8.2; CE01308; WBGene00006519; cox-6A.
DR eggNOG; KOG3469; Eukaryota.
DR GeneTree; ENSGT00940000168355; -.
DR HOGENOM; CLU_122515_0_2_1; -.
DR InParanoid; Q20779; -.
DR OMA; HKKHMSH; -.
DR OrthoDB; 1591077at2759; -.
DR PhylomeDB; Q20779; -.
DR UniPathway; UPA00705; -.
DR PRO; PR:Q20779; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006519; Expressed in larva and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR CDD; cd00925; Cyt_c_Oxidase_VIa; 1.
DR Gene3D; 4.10.95.10; -; 1.
DR InterPro; IPR001349; Cyt_c_oxidase_su6a.
DR InterPro; IPR018507; Cyt_c_oxidase_su6a_CS.
DR InterPro; IPR036418; Cyt_c_oxidase_su6a_sf.
DR PANTHER; PTHR11504; PTHR11504; 1.
DR Pfam; PF02046; COX6A; 1.
DR SUPFAM; SSF81411; SSF81411; 1.
DR PROSITE; PS01329; COX6A; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..19
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 20..128
FT /note="Cytochrome c oxidase subunit 6A, mitochondrial"
FT /id="PRO_0000006125"
FT TOPO_DOM 20..53
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..128
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
SQ SEQUENCE 128 AA; 14743 MW; EF4EA56A1CE6A233 CRC64;
MNRLAQPATR SVVKTFQRKS SGSFYGSNNV EGFKESYVTP LKQAHNASET WKKIFFIASI
PCLALTMYAA FKDHKKHMSH ERPEHVEYAF LNVRNKPFPW SDGNHSLFHN KAEQFVPGVG
FEADREKH
