ID   COX6A_CYPCA             Reviewed;         102 AA.
AC   O13082;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Cytochrome c oxidase subunit 6A, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase polypeptide VIa;
DE   Flags: Precursor;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=9107314; DOI=10.1016/s0005-2728(97)00011-x;
RA   Huttemann M., Exner S., Arnold S., Lottspeich F., Kadenbach B.;
RT   "The cDNA sequences of cytochrome c oxidase subunit VIa from carp and
RT   rainbow trout suggest the absence of isoforms in fishes.";
RL   Biochim. Biophys. Acta 1319:14-18(1997).
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules unsing 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P32799}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:P32799}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC       COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC       are encoded in the nuclear genome. The complex exists as a monomer or a
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
CC       {ECO:0000250|UniProtKB:P12074}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P12074}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P12074}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 6A family.
CC       {ECO:0000305}.
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DR   EMBL; U83907; AAB58361.1; -; mRNA.
DR   AlphaFoldDB; O13082; -.
DR   SMR; O13082; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00925; Cyt_c_Oxidase_VIa; 1.
DR   Gene3D; 4.10.95.10; -; 1.
DR   InterPro; IPR001349; Cyt_c_oxidase_su6a.
DR   InterPro; IPR018507; Cyt_c_oxidase_su6a_CS.
DR   InterPro; IPR036418; Cyt_c_oxidase_su6a_sf.
DR   PANTHER; PTHR11504; PTHR11504; 1.
DR   Pfam; PF02046; COX6A; 1.
DR   PIRSF; PIRSF000277; COX6A1; 1.
DR   SUPFAM; SSF81411; SSF81411; 1.
DR   PROSITE; PS01329; COX6A; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..14
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           15..102
FT                   /note="Cytochrome c oxidase subunit 6A, mitochondrial"
FT                   /id="PRO_0000006123"
FT   TOPO_DOM        15..25
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P07471"
FT   TRANSMEM        26..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P07471"
FT   TOPO_DOM        51..102
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P07471"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   102 AA;  11175 MW;  FA45C58A08FE5B5D CRC64;
     MAMSPAATVA RRRLAAASQG SHEGGARTWK ILSFVLALPG VGVCMANAYM KMQAHSHDPP
     EFVPYPHLRI RTKPWPWGDG NHSLFHNAHT NALPTGYEGP HH