COX6_DICDI
ID COX6_DICDI Reviewed; 93 AA.
AC P26310; Q54T04;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Cytochrome c oxidase polypeptide 6, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide VI;
GN Name=cxfA; Synonyms=cox6; ORFNames=DDB_G0282097;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-18.
RC STRAIN=AX3;
RX PubMed=1650252; DOI=10.1016/0167-4781(91)90180-t;
RA Rizzuto R., Sandona D., Capaldi R.A., Bisson R.;
RT "Characterization of a cDNA encoding subunit VI of cytochrome c oxidase
RT from the slime mold Dictyostelium discoideum.";
RL Biochim. Biophys. Acta 1089:386-388(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P00424}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of a catalytic core of 3 subunits and
CC seevral supernumerary subunits. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1
CC complex, complex III, CIII). {ECO:0000250|UniProtKB:P00424}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P00424}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P00424}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase IV family.
CC {ECO:0000305}.
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DR EMBL; X55672; CAA39207.1; -; mRNA.
DR EMBL; AAFI02000045; EAL66374.1; -; Genomic_DNA.
DR PIR; S17190; OGDO6.
DR RefSeq; XP_640351.1; XM_635259.1.
DR AlphaFoldDB; P26310; -.
DR SMR; P26310; -.
DR PaxDb; P26310; -.
DR EnsemblProtists; EAL66374; EAL66374; DDB_G0282097.
DR GeneID; 8623406; -.
DR KEGG; ddi:DDB_G0282097; -.
DR dictyBase; DDB_G0282097; cxfA.
DR eggNOG; ENOG502RIDF; Eukaryota.
DR HOGENOM; CLU_2404152_0_0_1; -.
DR InParanoid; P26310; -.
DR OMA; RYPKGFK; -.
DR UniPathway; UPA00705; -.
DR PRO; PR:P26310; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:1650252"
FT CHAIN 2..93
FT /note="Cytochrome c oxidase polypeptide 6, mitochondrial"
FT /id="PRO_0000194086"
FT TOPO_DOM 2..33
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P00424"
FT TRANSMEM 34..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..93
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P00424"
SQ SEQUENCE 93 AA; 10666 MW; 6D73D3EA4A448A96 CRC64;
MSTGNESYNL RYPKGFKGYP YNMYKLEGYG TPKGYITLIG VVATLTVSGL FFAKTRSNKR
EYPTHNKEWR AKTLAYAKET NADPIYQLPK DKI
