ID   COX7B_RAT               Reviewed;          80 AA.
AC   P80431; Q6AYA9; Q7TPH1;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 3.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Cytochrome c oxidase subunit 7B, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase polypeptide VIIb;
DE   Flags: Precursor;
GN   Name=Cox7b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain stem;
RA   Zhou L., Guo J., Ma Y.;
RT   "Rattus norvegicus cytochrome c oxidase subunit VIIb.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 25-34.
RC   STRAIN=Wistar; TISSUE=Liver;
RX   PubMed=7601105; DOI=10.1111/j.1432-1033.1995.tb20556.x;
RA   Schaegger H., Noack H., Halangk W., Brandt U., von Jagow G.;
RT   "Cytochrome-c oxidase in developing rat heart. Enzymic properties and
RT   amino-terminal sequences suggest identity of the fetal heart and the adult
RT   liver isoform.";
RL   Eur. J. Biochem. 230:235-241(1995).
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix (By similarity). Plays a role in
CC       proper central nervous system (CNS) development in vertebrates (By
CC       similarity). {ECO:0000250|UniProtKB:P13183,
CC       ECO:0000250|UniProtKB:P24311}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:P13183}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC       COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC       are encoded in the nuclear genome. The complex exists as a monomer or a
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
CC       {ECO:0000250|UniProtKB:P13183}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P13183}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P13183}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase VIIb family.
CC       {ECO:0000305}.
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DR   EMBL; AY339885; AAP92332.1; -; mRNA.
DR   EMBL; BC079123; AAH79123.1; -; mRNA.
DR   PIR; S65387; S65387.
DR   RefSeq; NP_877971.2; NM_182819.2.
DR   AlphaFoldDB; P80431; -.
DR   CORUM; P80431; -.
DR   STRING; 10116.ENSRNOP00000054370; -.
DR   iPTMnet; P80431; -.
DR   PhosphoSitePlus; P80431; -.
DR   PaxDb; P80431; -.
DR   PRIDE; P80431; -.
DR   Ensembl; ENSRNOT00000090007; ENSRNOP00000074109; ENSRNOG00000054689.
DR   GeneID; 303393; -.
DR   KEGG; rno:303393; -.
DR   UCSC; RGD:727789; rat.
DR   CTD; 1349; -.
DR   RGD; 727789; Cox7b.
DR   eggNOG; ENOG502S9DG; Eukaryota.
DR   GeneTree; ENSGT00390000012178; -.
DR   HOGENOM; CLU_172656_0_0_1; -.
DR   InParanoid; P80431; -.
DR   OMA; GATFCIT; -.
DR   PhylomeDB; P80431; -.
DR   TreeFam; TF105068; -.
DR   Reactome; R-RNO-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-RNO-611105; Respiratory electron transport.
DR   Reactome; R-RNO-9707564; Cytoprotection by HMOX1.
DR   UniPathway; UPA00705; -.
DR   PRO; PR:P80431; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000054689; Expressed in heart and 20 other tissues.
DR   Genevisible; P80431; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISO:RGD.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0045277; C:respiratory chain complex IV; IBA:GO_Central.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 4.10.51.10; -; 1.
DR   InterPro; IPR008433; Cyt_c_oxidase_suVIIB.
DR   InterPro; IPR023272; Cyt_c_oxidase_suVIIB_dom_sf.
DR   PANTHER; PTHR16716; PTHR16716; 1.
DR   Pfam; PF05392; COX7B; 1.
DR   SUPFAM; SSF81423; SSF81423; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..24
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:7601105"
FT   CHAIN           25..80
FT                   /note="Cytochrome c oxidase subunit 7B, mitochondrial"
FT                   /id="PRO_0000006160"
FT   TOPO_DOM        25..32
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P13183"
FT   TRANSMEM        33..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P13183"
FT   TOPO_DOM        60..80
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P13183"
FT   CONFLICT        9
FT                   /note="L -> I (in Ref. 1; AAP92332)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   80 AA;  8995 MW;  A0E9B8E8BD6CCBF7 CRC64;
     MLPLAKNALS RLQVRSIQQV VARQSHQKKT PTFHDKYGNA VLAGGSIFCI SAWTYTATQI
     GIEWNLSPVG RVTPKEWRDQ