COX7C_PIG
ID COX7C_PIG Reviewed; 63 AA.
AC Q1W0Y2; A1XQT3; Q9TRE9;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide VIIc;
DE Flags: Precursor;
GN Name=COX7C; Synonyms=COX7C1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang T., Xiong Y.-Z.;
RT "Cloning and sequencing the full-length cDNA of pig COX7C gene.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Longissimus dorsi muscle;
RA Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT muscle library.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 17-63.
RC TISSUE=Intestine;
RX PubMed=8396926; DOI=10.1006/bbrc.1993.2108;
RA Sillard R., Joernvall H., Mutt V.;
RT "Characterization of porcine intestinal cytochrome c oxidase subunit VIIc,
RT purified by affinity chromatography.";
RL Biochem. Biophys. Res. Commun. 195:746-750(1993).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04039}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P04039}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC are encoded in the nuclear genome. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC Interacts with RAB5IF (By similarity). {ECO:0000250|UniProtKB:P00430,
CC ECO:0000250|UniProtKB:P15954}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P00430}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P00430}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase VIIc family.
CC {ECO:0000305}.
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DR EMBL; DQ456972; ABD98458.1; -; mRNA.
DR EMBL; DQ456973; ABD98459.1; -; mRNA.
DR EMBL; DQ629155; ABK55639.1; -; mRNA.
DR PIR; PN0607; PN0607.
DR RefSeq; NP_001090943.1; NM_001097474.1.
DR RefSeq; XP_013850421.1; XM_013994967.1.
DR AlphaFoldDB; Q1W0Y2; -.
DR SMR; Q1W0Y2; -.
DR STRING; 9823.ENSSSCP00000015039; -.
DR PaxDb; Q1W0Y2; -.
DR PeptideAtlas; Q1W0Y2; -.
DR PRIDE; Q1W0Y2; -.
DR Ensembl; ENSSSCT00000063285; ENSSSCP00000048132; ENSSSCG00000040325.
DR Ensembl; ENSSSCT00005007429; ENSSSCP00005004318; ENSSSCG00005004957.
DR Ensembl; ENSSSCT00005007442; ENSSSCP00005004325; ENSSSCG00005004957.
DR Ensembl; ENSSSCT00015008457; ENSSSCP00015003413; ENSSSCG00015006366.
DR Ensembl; ENSSSCT00025003198; ENSSSCP00025001178; ENSSSCG00025002477.
DR Ensembl; ENSSSCT00030066375; ENSSSCP00030030404; ENSSSCG00030047549.
DR Ensembl; ENSSSCT00035107019; ENSSSCP00035046174; ENSSSCG00035078393.
DR Ensembl; ENSSSCT00045055691; ENSSSCP00045038841; ENSSSCG00045032627.
DR Ensembl; ENSSSCT00050050884; ENSSSCP00050021309; ENSSSCG00050037765.
DR Ensembl; ENSSSCT00055055695; ENSSSCP00055044451; ENSSSCG00055028128.
DR Ensembl; ENSSSCT00060086125; ENSSSCP00060037241; ENSSSCG00060063156.
DR Ensembl; ENSSSCT00065021399; ENSSSCP00065008666; ENSSSCG00065016135.
DR Ensembl; ENSSSCT00070014666; ENSSSCP00070012117; ENSSSCG00070007583.
DR Ensembl; ENSSSCT00070014677; ENSSSCP00070012127; ENSSSCG00070007583.
DR GeneID; 100037990; -.
DR KEGG; ssc:100037990; -.
DR CTD; 1350; -.
DR VGNC; VGNC:99628; COX7C.
DR eggNOG; KOG4527; Eukaryota.
DR GeneTree; ENSGT00390000018086; -.
DR HOGENOM; CLU_194769_0_0_1; -.
DR InParanoid; Q1W0Y2; -.
DR OMA; MMAAFFG; -.
DR OrthoDB; 1642074at2759; -.
DR TreeFam; TF105069; -.
DR Reactome; R-SSC-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-SSC-611105; Respiratory electron transport.
DR Reactome; R-SSC-9707564; Cytoprotection by HMOX1.
DR UniPathway; UPA00705; -.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000040325; Expressed in heart left ventricle and 46 other tissues.
DR Genevisible; Q1W0Y2; SS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:Ensembl.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR CDD; cd00929; Cyt_c_Oxidase_VIIc; 1.
DR Gene3D; 4.10.49.10; -; 1.
DR InterPro; IPR004202; COX7C/Cox8.
DR InterPro; IPR036636; COX7C/Cox8_sf.
DR PANTHER; PTHR13313; PTHR13313; 1.
DR Pfam; PF02935; COX7C; 1.
DR SUPFAM; SSF81427; SSF81427; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..16
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:8396926"
FT CHAIN 17..63
FT /note="Cytochrome c oxidase subunit 7C, mitochondrial"
FT /id="PRO_0000245342"
FT TOPO_DOM 17..33
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P00430"
FT TRANSMEM 34..60
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:P00430"
FT TOPO_DOM 61..63
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P00430"
FT MOD_RES 25
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P17665"
FT MOD_RES 25
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P17665"
SQ SEQUENCE 63 AA; 7347 MW; C6A2AD4AAF314C7B CRC64;
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLAM MTLYFGSGFA APFFIVRHQL
LKK
