COX7R_MOUSE
ID COX7R_MOUSE Reviewed; 111 AA.
AC Q61387;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Cytochrome c oxidase subunit 7A-related protein, mitochondrial;
DE AltName: Full=Cytochrome c oxidase subunit VIIa-related protein;
DE AltName: Full=Silica-induced gene 81 protein;
DE Short=SIG-81;
DE AltName: Full=Supercomplex assembly factor I {ECO:0000303|PubMed:23812712};
DE Flags: Precursor;
GN Name=Cox7a2l; Synonyms=Cox7rp, Scaf1, Silg81 {ECO:0000303|PubMed:23812712};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC TISSUE=Macrophage;
RX PubMed=7868905;
RA Segade F., Claudio E., Wrobel K., Ramos S., Lazo P.S.;
RT "Isolation of nine gene sequences induced by silica in murine
RT macrophages.";
RL J. Immunol. 154:2384-2392(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23857330; DOI=10.1038/ncomms3147;
RA Ikeda K., Shiba S., Horie-Inoue K., Shimokata K., Inoue S.;
RT "A stabilizing factor for mitochondrial respiratory supercomplex assembly
RT regulates energy metabolism in muscle.";
RL Nat. Commun. 4:2147-2147(2013).
RN [4]
RP FUNCTION, AND INTERACTION WITH MITOCHONDRIAL RESPIRATORY SUPERCOMPLEX.
RX PubMed=23812712; DOI=10.1126/science.1230381;
RA Lapuente-Brun E., Moreno-Loshuertos R., Acin-Perez R., Latorre-Pellicer A.,
RA Colas C., Balsa E., Perales-Clemente E., Quiros P.M., Calvo E.,
RA Rodriguez-Hernandez M.A., Navas P., Cruz R., Carracedo A., Lopez-Otin C.,
RA Perez-Martos A., Fernandez-Silva P., Fernandez-Vizarra E., Enriquez J.A.;
RT "Supercomplex assembly determines electron flux in the mitochondrial
RT electron transport chain.";
RL Science 340:1567-1570(2013).
CC -!- FUNCTION: Involved in the regulation of oxidative phosphorylation and
CC energy metabolism (PubMed:23857330, PubMed:23812712). Necessary for the
CC assembly of mitochondrial respiratory supercomplex (PubMed:23857330,
CC PubMed:23812712). {ECO:0000269|PubMed:23812712,
CC ECO:0000269|PubMed:23857330}.
CC -!- SUBUNIT: Interacts with the mitochondrial respiratory supercomplex.
CC {ECO:0000269|PubMed:23812712}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
CC -!- INDUCTION: By estrogen and silica. {ECO:0000269|PubMed:7868905}.
CC -!- DISRUPTION PHENOTYPE: Knockout homozygous mice manifest decreased
CC mitochondrial respiratory activities and impaired formation of
CC mitochondrial supercomplexes in muscles. KO animals have muscle
CC weakness and exhibit heat production failure in the cold.
CC {ECO:0000269|PubMed:23857330}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase VIIa family.
CC {ECO:0000305}.
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DR EMBL; X80899; CAA56861.1; -; mRNA.
DR CCDS; CCDS28995.1; -.
DR RefSeq; NP_033213.1; NM_009187.3.
DR AlphaFoldDB; Q61387; -.
DR SMR; Q61387; -.
DR BioGRID; 203253; 2.
DR IntAct; Q61387; 2.
DR iPTMnet; Q61387; -.
DR PhosphoSitePlus; Q61387; -.
DR EPD; Q61387; -.
DR jPOST; Q61387; -.
DR MaxQB; Q61387; -.
DR PRIDE; Q61387; -.
DR ProteomicsDB; 283797; -.
DR Antibodypedia; 29742; 159 antibodies from 28 providers.
DR DNASU; 20463; -.
DR Ensembl; ENSMUST00000025095; ENSMUSP00000025095; ENSMUSG00000024248.
DR GeneID; 20463; -.
DR KEGG; mmu:20463; -.
DR UCSC; uc008dsc.2; mouse.
DR CTD; 9167; -.
DR MGI; MGI:106015; Cox7a2l.
DR VEuPathDB; HostDB:ENSMUSG00000024248; -.
DR GeneTree; ENSGT00940000154815; -.
DR InParanoid; Q61387; -.
DR OMA; YPKYDYA; -.
DR PhylomeDB; Q61387; -.
DR Reactome; R-MMU-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-9707564; Cytoprotection by HMOX1.
DR BioGRID-ORCS; 20463; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Cox7a2l; mouse.
DR PRO; PR:Q61387; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q61387; protein.
DR Bgee; ENSMUSG00000024248; Expressed in spleen and 84 other tissues.
DR ExpressionAtlas; Q61387; baseline and differential.
DR Genevisible; Q61387; MM.
DR GO; GO:0005746; C:mitochondrial respirasome; IDA:UniProtKB.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IDA:UniProtKB.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; IMP:UniProtKB.
DR CDD; cd00928; Cyt_c_Oxidase_VIIa; 1.
DR Gene3D; 4.10.91.10; -; 1.
DR InterPro; IPR039297; COX7a.
DR InterPro; IPR017267; Cyt_c_oxidase_su7a-rel_mt.
DR InterPro; IPR036539; Cyt_c_oxidase_su7a_sf.
DR InterPro; IPR003177; Cytc_oxidase_su7a_met.
DR PANTHER; PTHR10510; PTHR10510; 1.
DR PANTHER; PTHR10510:SF2; PTHR10510:SF2; 1.
DR Pfam; PF02238; COX7a; 1.
DR PIRSF; PIRSF037710; COX7A-rel_mt; 1.
DR SUPFAM; SSF81419; SSF81419; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..54
FT /note="Mitochondrion"
FT CHAIN 55..111
FT /note="Cytochrome c oxidase subunit 7A-related protein,
FT mitochondrial"
FT /id="PRO_0000006155"
FT MOD_RES 68
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O14548"
SQ SEQUENCE 111 AA; 12399 MW; 542F20F0ADD9F4E5 CRC64;
MYYKFSSFTQ KLAGAWASEA YTPQGLKPVS TEAPPIIFAT PTKLTSSVTA YDYSGKNKVP
ELQKFFQKAD GFHLKRGLPD QMLYRTTMAL TLGGTIYCLI ALYMASQPRN K
