COX8A_PONPY
ID COX8A_PONPY Reviewed; 69 AA.
AC P60183; Q8SPF1;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Cytochrome c oxidase subunit 8A, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide VIII-liver/heart;
DE AltName: Full=Cytochrome c oxidase subunit 8-2;
DE Flags: Precursor;
GN Name=COX8A; Synonyms=COX8, COX8L;
OS Pongo pygmaeus (Bornean orangutan).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S., Hirai M.,
RA Hashimoto K.;
RT "EST sequence screening of cynomolgus monkey cDNAs to find genes positively
RT selected between hominoid and old monkey lineages.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12716970; DOI=10.1073/pnas.0931463100;
RA Goldberg A., Wildman D.E., Schmidt T.R., Huttemann M., Goodman M.,
RA Weiss M.L., Grossman L.I.;
RT "Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid
RT primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5873-5878(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P10175}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC are encoded in the nuclear genome. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
CC {ECO:0000250|UniProtKB:P10176}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P10176}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P10176}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase VIII family.
CC {ECO:0000305}.
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DR EMBL; AB072329; BAB86879.1; -; Genomic_DNA.
DR EMBL; AY254812; AAP32245.1; -; Genomic_DNA.
DR EMBL; AY254811; AAP32245.1; JOINED; Genomic_DNA.
DR EMBL; CR858519; CAH90746.1; -; mRNA.
DR AlphaFoldDB; P60183; -.
DR SMR; P60183; -.
DR UniPathway; UPA00705; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR Gene3D; 4.10.81.10; -; 1.
DR InterPro; IPR003205; Cyt_c_oxidase_su8.
DR InterPro; IPR036548; Cyt_c_oxidase_su8_sf.
DR PANTHER; PTHR16717; PTHR16717; 1.
DR Pfam; PF02285; COX8; 1.
DR SUPFAM; SSF81431; SSF81431; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..25
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:P10176"
FT CHAIN 26..69
FT /note="Cytochrome c oxidase subunit 8A, mitochondrial"
FT /id="PRO_0000006195"
FT TOPO_DOM 26..36
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P10176"
FT TRANSMEM 37..60
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:P10175"
FT TOPO_DOM 61..69
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P10176"
SQ SEQUENCE 69 AA; 7651 MW; E1736E52AE594382 CRC64;
MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEEKLGIMEL AVGLTSCFVT FLLPAGWILS
HLETYRRPE
