COX8C_HUMAN
ID COX8C_HUMAN Reviewed; 72 AA.
AC Q7Z4L0; Q495K7;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Cytochrome c oxidase subunit 8C, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide 8 isoform 3;
DE AltName: Full=Cytochrome c oxidase polypeptide VIII isoform 3;
DE Short=COX VIII-3;
DE AltName: Full=Cytochrome c oxidase subunit 8-3;
DE Short=COX8-3;
DE AltName: Full=Cytochrome c oxidase subunit VIIIC;
DE Flags: Precursor;
GN Name=COX8C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12909344; DOI=10.1016/s0378-1119(03)00604-8;
RA Huettemann M., Schmidt T.R., Grossman L.I.;
RT "A third isoform of cytochrome c oxidase subunit VIII is present in
RT mammals.";
RL Gene 312:95-102(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P10175}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or
CC COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C,
CC COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded
CC in the nuclear genome (By similarity). The complex exists as a monomer
CC or a dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC {ECO:0000250|UniProtKB:P10175}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P10175}.
CC -!- TISSUE SPECIFICITY: It is not yet known where COX8C is expressed.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase VIII family.
CC {ECO:0000305}.
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DR EMBL; AY161004; AAO26193.1; -; mRNA.
DR EMBL; BC101125; AAI01126.1; -; mRNA.
DR EMBL; BC101126; AAI01127.1; -; mRNA.
DR CCDS; CCDS9910.1; -.
DR RefSeq; NP_892016.1; NM_182971.2.
DR AlphaFoldDB; Q7Z4L0; -.
DR SMR; Q7Z4L0; -.
DR STRING; 9606.ENSP00000340568; -.
DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR BioMuta; COX8C; -.
DR DMDM; 41017026; -.
DR MassIVE; Q7Z4L0; -.
DR PaxDb; Q7Z4L0; -.
DR PeptideAtlas; Q7Z4L0; -.
DR PRIDE; Q7Z4L0; -.
DR Antibodypedia; 182; 22 antibodies from 12 providers.
DR DNASU; 341947; -.
DR Ensembl; ENST00000342144.3; ENSP00000340568.2; ENSG00000187581.3.
DR Ensembl; ENST00000620478.2; ENSP00000480706.1; ENSG00000277018.2.
DR GeneID; 341947; -.
DR KEGG; hsa:341947; -.
DR MANE-Select; ENST00000342144.3; ENSP00000340568.2; NM_182971.3; NP_892016.1.
DR UCSC; uc001ybt.2; human.
DR CTD; 341947; -.
DR GeneCards; COX8C; -.
DR HGNC; HGNC:24382; COX8C.
DR HPA; ENSG00000187581; Tissue enriched (testis).
DR MIM; 616855; gene.
DR neXtProt; NX_Q7Z4L0; -.
DR OpenTargets; ENSG00000187581; -.
DR PharmGKB; PA134909890; -.
DR VEuPathDB; HostDB:ENSG00000187581; -.
DR eggNOG; ENOG502TKKT; Eukaryota.
DR GeneTree; ENSGT00390000006255; -.
DR HOGENOM; CLU_202012_0_0_1; -.
DR InParanoid; Q7Z4L0; -.
DR OMA; FLTPCGY; -.
DR OrthoDB; 81334at2759; -.
DR PhylomeDB; Q7Z4L0; -.
DR PathwayCommons; Q7Z4L0; -.
DR UniPathway; UPA00705; -.
DR BioGRID-ORCS; 341947; 11 hits in 1068 CRISPR screens.
DR GenomeRNAi; 341947; -.
DR Pharos; Q7Z4L0; Tdark.
DR PRO; PR:Q7Z4L0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q7Z4L0; protein.
DR Bgee; ENSG00000187581; Expressed in right testis and 80 other tissues.
DR Genevisible; Q7Z4L0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0045277; C:respiratory chain complex IV; IBA:GO_Central.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR Gene3D; 4.10.81.10; -; 1.
DR InterPro; IPR003205; Cyt_c_oxidase_su8.
DR InterPro; IPR036548; Cyt_c_oxidase_su8_sf.
DR PANTHER; PTHR16717; PTHR16717; 1.
DR Pfam; PF02285; COX8; 1.
DR SUPFAM; SSF81431; SSF81431; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 30..72
FT /note="Cytochrome c oxidase subunit 8C, mitochondrial"
FT /id="PRO_0000006201"
FT TOPO_DOM 30..40
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P10175"
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:P10175"
FT TOPO_DOM 65..72
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P10175"
SQ SEQUENCE 72 AA; 8129 MW; 53C47863EC761638 CRC64;
MPLLRGRCPA RRHYRRLALL GLQPAPRFAH SGPPRQRPLS AAEMAVGLVV FFTTFLTPAA
YVLGNLKQFR RN
