COX9_ASHGO
ID COX9_ASHGO Reviewed; 60 AA.
AC Q757F0;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Cytochrome c oxidase subunit 9, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide VIIA;
DE Flags: Precursor;
GN Name=COX9; OrderedLocusNames=AER063W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P07255}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P07255}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of a catalytic core of 3 subunits and
CC several supernumerary subunits. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1
CC complex, complex III, CIII). {ECO:0000250|UniProtKB:P07255}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P07255}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P07255}.
CC -!- SIMILARITY: Belongs to the fungal cytochrome c oxidase subunit 7a
CC family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52747.1; -; Genomic_DNA.
DR RefSeq; NP_984923.1; NM_210277.1.
DR AlphaFoldDB; Q757F0; -.
DR SMR; Q757F0; -.
DR STRING; 33169.AAS52747; -.
DR EnsemblFungi; AAS52747; AAS52747; AGOS_AER063W.
DR GeneID; 4621126; -.
DR KEGG; ago:AGOS_AER063W; -.
DR eggNOG; ENOG502SBM8; Eukaryota.
DR HOGENOM; CLU_196969_0_0_1; -.
DR InParanoid; Q757F0; -.
DR OMA; ASYWWWG; -.
DR UniPathway; UPA00705; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR InterPro; IPR014368; Cyt_c_oxidase_su7a_fun.
DR PIRSF; PIRSF000283; COX9; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..57
FT /note="Cytochrome c oxidase subunit 9, mitochondrial"
FT /id="PRO_0000041763"
FT PROPEP 58..60
FT /note="Removed in mature form"
FT /evidence="ECO:0000250|UniProtKB:P07255"
FT /id="PRO_0000041764"
FT TOPO_DOM 1..18
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P07255"
FT TRANSMEM 19..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..57
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P07255"
SQ SEQUENCE 60 AA; 6714 MW; 7089BF0AA36815B6 CRC64;
MSAIAPITGS LKKRIMKDIA VGMGLGTVLG SYWWWGFHKP KIAARENYYT QLAEQKAAEE
