COX9_CANGA
ID COX9_CANGA Reviewed; 60 AA.
AC Q6FWE8;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Cytochrome c oxidase subunit 9, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide VIIA;
DE Flags: Precursor;
GN Name=COX9; OrderedLocusNames=CAGL0D00748g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P07255}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P07255}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of a catalytic core of 3 subunits and
CC several supernumerary subunits. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1
CC complex, complex III, CIII). {ECO:0000250|UniProtKB:P07255}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P07255}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P07255}.
CC -!- SIMILARITY: Belongs to the fungal cytochrome c oxidase subunit 7a
CC family. {ECO:0000305}.
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DR EMBL; CR380950; CAG58357.1; -; Genomic_DNA.
DR RefSeq; XP_445446.1; XM_445446.1.
DR AlphaFoldDB; Q6FWE8; -.
DR SMR; Q6FWE8; -.
DR STRING; 5478.XP_445446.1; -.
DR EnsemblFungi; CAG58357; CAG58357; CAGL0D00748g.
DR GeneID; 2887216; -.
DR KEGG; cgr:CAGL0D00748g; -.
DR CGD; CAL0128513; CAGL0D00748g.
DR VEuPathDB; FungiDB:CAGL0D00748g; -.
DR eggNOG; ENOG502SBM8; Eukaryota.
DR HOGENOM; CLU_196969_0_0_1; -.
DR InParanoid; Q6FWE8; -.
DR OMA; ASYWWWG; -.
DR UniPathway; UPA00705; -.
DR Proteomes; UP000002428; Chromosome D.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:EnsemblFungi.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EnsemblFungi.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:EnsemblFungi.
DR InterPro; IPR014368; Cyt_c_oxidase_su7a_fun.
DR PIRSF; PIRSF000283; COX9; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..57
FT /note="Cytochrome c oxidase subunit 9, mitochondrial"
FT /id="PRO_0000041765"
FT PROPEP 58..60
FT /note="Removed in mature form"
FT /evidence="ECO:0000250|UniProtKB:P07255"
FT /id="PRO_0000041766"
FT TOPO_DOM 1..15
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P07255"
FT TRANSMEM 16..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..57
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P07255"
SQ SEQUENCE 60 AA; 6816 MW; BDB2685372A513AA CRC64;
MSALAPITGT LKKRIITDIV IGFSLGGVMA SYWWWGFHKN VIDRREAFYA DLAEKKKAEN
