COXA_THET8
ID COXA_THET8 Reviewed; 34 AA.
AC P82543; Q5SJ81;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Cytochrome c oxidase polypeptide 2A;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c ba(3) subunit IIA;
DE AltName: Full=Cytochrome c oxidase polypeptide IIA;
DE AltName: Full=Cytochrome cba3 subunit 2A;
GN Name=cbaD; OrderedLocusNames=TTHA1133;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP PROTEIN SEQUENCE, FORMYLATION AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=11152118; DOI=10.1110/ps.9.11.2068;
RA Soulimane T., Than M.E., Dewor M., Huber R., Buse G.;
RT "Primary structure of a novel subunit in ba3-cytochrome oxidase from
RT Thermus thermophilus.";
RL Protein Sci. 9:2068-2073(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RX PubMed=10775261; DOI=10.1093/emboj/19.8.1766;
RA Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.;
RT "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from
RT Thermus thermophilus.";
RL EMBO J. 19:1766-1776(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC -!- MASS SPECTROMETRY: Mass=3794.6; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11152118};
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DR EMBL; AP008226; BAD70956.1; -; Genomic_DNA.
DR RefSeq; WP_008632613.1; NC_006461.1.
DR RefSeq; YP_144399.1; NC_006461.1.
DR PDB; 1EHK; X-ray; 2.40 A; C=2-34.
DR PDB; 1XME; X-ray; 2.30 A; C=1-34.
DR PDB; 2QPD; X-ray; 3.25 A; C=1-34.
DR PDB; 2QPE; X-ray; 2.90 A; C=1-34.
DR PDB; 3BVD; X-ray; 3.37 A; C=1-34.
DR PDB; 3EH3; X-ray; 3.10 A; C=2-34.
DR PDB; 3EH4; X-ray; 2.90 A; C=2-34.
DR PDB; 3EH5; X-ray; 2.80 A; C=2-34.
DR PDB; 3QJQ; X-ray; 2.90 A; C=1-34.
DR PDB; 3QJR; X-ray; 3.20 A; C=1-34.
DR PDB; 3QJS; X-ray; 2.80 A; C=1-34.
DR PDB; 3QJT; X-ray; 2.95 A; C=1-34.
DR PDB; 3QJU; X-ray; 2.90 A; C=1-34.
DR PDB; 3QJV; X-ray; 2.80 A; C=1-34.
DR PDB; 3S33; X-ray; 4.45 A; C=2-34.
DR PDB; 3S38; X-ray; 4.20 A; C=2-34.
DR PDB; 3S39; X-ray; 4.80 A; C=2-34.
DR PDB; 3S3A; X-ray; 4.25 A; C=2-34.
DR PDB; 3S3B; X-ray; 3.30 A; C=2-34.
DR PDB; 3S3C; X-ray; 4.00 A; C=2-34.
DR PDB; 3S3D; X-ray; 3.75 A; C=2-34.
DR PDB; 3S8F; X-ray; 1.80 A; C=1-34.
DR PDB; 3S8G; X-ray; 1.80 A; C=1-34.
DR PDB; 4FA7; X-ray; 2.50 A; C=1-34.
DR PDB; 4FAA; X-ray; 2.80 A; C=1-34.
DR PDB; 4G70; X-ray; 2.60 A; C=1-34.
DR PDB; 4G71; X-ray; 2.90 A; C=1-34.
DR PDB; 4G72; X-ray; 3.19 A; C=1-34.
DR PDB; 4G7Q; X-ray; 2.60 A; C=1-34.
DR PDB; 4G7R; X-ray; 3.05 A; C=1-34.
DR PDB; 4G7S; X-ray; 2.00 A; C=1-34.
DR PDB; 4GP4; X-ray; 2.80 A; C=1-34.
DR PDB; 4GP5; X-ray; 2.70 A; C=1-34.
DR PDB; 4GP8; X-ray; 2.80 A; C=1-34.
DR PDB; 4N4Y; X-ray; 2.90 A; C=1-34.
DR PDB; 5NDC; X-ray; 2.30 A; C=1-34.
DR PDBsum; 1EHK; -.
DR PDBsum; 1XME; -.
DR PDBsum; 2QPD; -.
DR PDBsum; 2QPE; -.
DR PDBsum; 3BVD; -.
DR PDBsum; 3EH3; -.
DR PDBsum; 3EH4; -.
DR PDBsum; 3EH5; -.
DR PDBsum; 3QJQ; -.
DR PDBsum; 3QJR; -.
DR PDBsum; 3QJS; -.
DR PDBsum; 3QJT; -.
DR PDBsum; 3QJU; -.
DR PDBsum; 3QJV; -.
DR PDBsum; 3S33; -.
DR PDBsum; 3S38; -.
DR PDBsum; 3S39; -.
DR PDBsum; 3S3A; -.
DR PDBsum; 3S3B; -.
DR PDBsum; 3S3C; -.
DR PDBsum; 3S3D; -.
DR PDBsum; 3S8F; -.
DR PDBsum; 3S8G; -.
DR PDBsum; 4FA7; -.
DR PDBsum; 4FAA; -.
DR PDBsum; 4G70; -.
DR PDBsum; 4G71; -.
DR PDBsum; 4G72; -.
DR PDBsum; 4G7Q; -.
DR PDBsum; 4G7R; -.
DR PDBsum; 4G7S; -.
DR PDBsum; 4GP4; -.
DR PDBsum; 4GP5; -.
DR PDBsum; 4GP8; -.
DR PDBsum; 4N4Y; -.
DR PDBsum; 5NDC; -.
DR AlphaFoldDB; P82543; -.
DR SMR; P82543; -.
DR IntAct; P82543; 1.
DR STRING; 300852.55772515; -.
DR DrugBank; DB02451; B-nonylglucoside.
DR TCDB; 3.D.4.2.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR EnsemblBacteria; BAD70956; BAD70956; BAD70956.
DR GeneID; 3168186; -.
DR KEGG; ttj:TTHA1133; -.
DR PATRIC; fig|300852.9.peg.1112; -.
DR eggNOG; ENOG5032GEU; Bacteria.
DR HOGENOM; CLU_220268_1_0_0; -.
DR EvolutionaryTrace; P82543; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR InterPro; IPR012538; Cyt_c_oxidase_su2a.
DR InterPro; IPR036246; Cyt_c_oxidase_su2a_ba3.
DR Pfam; PF08113; CoxIIa; 1.
DR SUPFAM; SSF81473; SSF81473; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Direct protein sequencing; Electron transport;
KW Formylation; Hydrogen ion transport; Ion transport; Membrane;
KW Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..34
FT /note="Cytochrome c oxidase polypeptide 2A"
FT /id="PRO_0000183934"
FT TRANSMEM 4..34
FT /note="Helical"
FT MOD_RES 1
FT /note="N-formylmethionine"
FT /evidence="ECO:0000269|PubMed:11152118"
FT HELIX 6..32
FT /evidence="ECO:0007829|PDB:3S8F"
SQ SEQUENCE 34 AA; 3767 MW; F473EB7D0B179FBB CRC64;
MEEKPKGALA VILVLTLTIL VFWLGVYAVF FARG
