ID   COXE_DICDI              Reviewed;          53 AA.
AC   P20609; Q54Z10;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Cytochrome c oxidase subunit 7e;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome c oxidase polypeptide VIIe;
GN   Name=cxgE; Synonyms=cox7e; ORFNames=DDB_G0277837;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RX   PubMed=2174548; DOI=10.1093/nar/18.22.6711;
RA   Rizzuto R., Sandona D., Capaldi R.A., Bisson R.;
RT   "Nucleotide sequence of the cDNA encoding subunit VIIe of cytochrome c
RT   oxidase from the slime mold Dictyostelium discoideum.";
RL   Nucleic Acids Res. 18:6711-6711(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX3;
RX   PubMed=9049303; DOI=10.1093/emboj/16.4.739;
RA   Bisson R., Vettore S., Aratri E., Sandona D.;
RT   "Subunit change in cytochrome c oxidase: identification of the oxygen
RT   switch in Dictyostelium.";
RL   EMBO J. 16:739-749(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-35.
RX   PubMed=2155132; DOI=10.1016/0014-5793(90)80660-b;
RA   Capaldi R.A., Zhang Y.-Z., Rizzuto R., Sandona D., Schiavo G., Bisson R.;
RT   "The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium
RT   discoideum derive from a common ancestor.";
RL   FEBS Lett. 261:158-160(1990).
CC   -!- FUNCTION: This protein is one of the nuclear-coded polypeptide chains
CC       of cytochrome c oxidase, the terminal oxidase in mitochondrial electron
CC       transport.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Slime mold cytochrome c oxidase consists of at least seven
CC       different polypeptides species, subunits I, II, III, IV, V, VI, and
CC       VIIe/s in order of MW.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC   -!- DEVELOPMENTAL STAGE: When cells enter the stationary phase of growth,
CC       during the vegetative state, subunit VIIe is replaced by VIIs. The
CC       switching depends on the oxygen tension.
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DR   EMBL; X55673; CAA39208.1; -; mRNA.
DR   EMBL; X99344; CAA67724.1; -; Genomic_DNA.
DR   EMBL; AAFI02000023; EAL68091.1; -; Genomic_DNA.
DR   PIR; S13105; S13105.
DR   RefSeq; XP_642042.1; XM_636950.1.
DR   AlphaFoldDB; P20609; -.
DR   SMR; P20609; -.
DR   PaxDb; P20609; -.
DR   EnsemblProtists; EAL68091; EAL68091; DDB_G0277837.
DR   GeneID; 8621254; -.
DR   KEGG; ddi:DDB_G0277837; -.
DR   dictyBase; DDB_G0277837; cxgE.
DR   HOGENOM; CLU_3072688_0_0_1; -.
DR   InParanoid; P20609; -.
DR   OMA; LIKMHIT; -.
DR   PRO; PR:P20609; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001666; P:response to hypoxia; IDA:dictyBase.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Translocase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2155132"
FT   CHAIN           2..53
FT                   /note="Cytochrome c oxidase subunit 7e"
FT                   /id="PRO_0000183908"
SQ   SEQUENCE   53 AA;  6110 MW;  1A365C9587D9CE76 CRC64;
     MSHALPALIK MHITKDIGYG LLLGIIPGVW FKYQIGQSIQ KREDFYAAYD KRN