COXM1_SCHPO
ID COXM1_SCHPO Reviewed; 104 AA.
AC O74347;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=COX assembly mitochondrial protein 1;
DE AltName: Full=Cx9C motif-containing protein 1;
GN Name=cmc1; ORFNames=SPBC21D10.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for mitochondrial cytochrome c oxidase (COX)
CC assembly and respiration. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Intermembrane side
CC {ECO:0000250}. Note=Imported into the mitochondria via the
CC mitochondrial mia40-erv1 machinery. {ECO:0000250}.
CC -!- DOMAIN: The twin Cx9C motifs are involved in the recognition by the
CC mitochondrial mia40-erv1 disulfide relay system and the subsequent
CC transfer of disulfide bonds by dithiol/disulfide exchange reactions to
CC the newly imported protein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CMC family. {ECO:0000305}.
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DR EMBL; CU329671; CAA20763.1; -; Genomic_DNA.
DR PIR; T11679; T11679.
DR RefSeq; NP_596006.1; NM_001021914.2.
DR AlphaFoldDB; O74347; -.
DR SMR; O74347; -.
DR BioGRID; 277014; 2.
DR STRING; 4896.SPBC21D10.07.1; -.
DR MaxQB; O74347; -.
DR PaxDb; O74347; -.
DR PRIDE; O74347; -.
DR EnsemblFungi; SPBC21D10.07.1; SPBC21D10.07.1:pep; SPBC21D10.07.
DR GeneID; 2540486; -.
DR KEGG; spo:SPBC21D10.07; -.
DR PomBase; SPBC21D10.07; cmc1.
DR VEuPathDB; FungiDB:SPBC21D10.07; -.
DR eggNOG; KOG4148; Eukaryota.
DR HOGENOM; CLU_169286_3_1_1; -.
DR InParanoid; O74347; -.
DR PhylomeDB; O74347; -.
DR PRO; PR:O74347; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISO:PomBase.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005507; F:copper ion binding; ISO:PomBase.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISO:PomBase.
DR InterPro; IPR013892; Cyt_c_biogenesis_Cmc1-like.
DR PANTHER; PTHR22977; PTHR22977; 1.
DR Pfam; PF08583; Cmc1; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Chaperone; Disulfide bond; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat.
FT CHAIN 1..104
FT /note="COX assembly mitochondrial protein 1"
FT /id="PRO_0000192946"
FT DOMAIN 10..52
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 13..23
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 34..44
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 13..44
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 23..34
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 104 AA; 12294 MW; 44B5C7292CFCAA6F CRC64;
MHPHLDVNNQ KQCADLIRAL EECHKSFGKF FGECNTIKYE LKACLTKDRN DKARLNRENA
RMRKKVIEEN RKKEEIEERI LTDRILQQER KKSHANEGAG DNNN
