COXM2_MOUSE
ID COXM2_MOUSE Reviewed; 79 AA.
AC Q8K199; Q8CEV6;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=COX assembly mitochondrial protein 2 homolog;
GN Name=Cmc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in cytochrome c oxidase biogenesis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CMC family. {ECO:0000305}.
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DR EMBL; AK002429; BAC24989.1; -; mRNA.
DR EMBL; AK013475; BAC25407.1; -; mRNA.
DR EMBL; BC027549; AAH27549.1; -; mRNA.
DR CCDS; CCDS40489.1; -.
DR RefSeq; NP_081120.2; NM_026844.3.
DR RefSeq; XP_006531345.1; XM_006531282.2.
DR RefSeq; XP_011246787.1; XM_011248485.2.
DR AlphaFoldDB; Q8K199; -.
DR SMR; Q8K199; -.
DR BioGRID; 211539; 2.
DR STRING; 10090.ENSMUSP00000120966; -.
DR iPTMnet; Q8K199; -.
DR PhosphoSitePlus; Q8K199; -.
DR EPD; Q8K199; -.
DR MaxQB; Q8K199; -.
DR PaxDb; Q8K199; -.
DR PeptideAtlas; Q8K199; -.
DR PRIDE; Q8K199; -.
DR ProteomicsDB; 277999; -.
DR DNASU; 66531; -.
DR Ensembl; ENSMUST00000148235; ENSMUSP00000120966; ENSMUSG00000014633.
DR GeneID; 66531; -.
DR KEGG; mmu:66531; -.
DR UCSC; uc009nom.1; mouse.
DR CTD; 56942; -.
DR MGI; MGI:1913781; Cmc2.
DR VEuPathDB; HostDB:ENSMUSG00000014633; -.
DR eggNOG; KOG4148; Eukaryota.
DR GeneTree; ENSGT01000000214745; -.
DR HOGENOM; CLU_169286_2_0_1; -.
DR InParanoid; Q8K199; -.
DR OMA; KCLRNEY; -.
DR OrthoDB; 1546992at2759; -.
DR TreeFam; TF314049; -.
DR BioGRID-ORCS; 66531; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Cmc2; mouse.
DR PRO; PR:Q8K199; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8K199; protein.
DR Bgee; ENSMUSG00000014633; Expressed in ileal epithelium and 264 other tissues.
DR ExpressionAtlas; Q8K199; baseline and differential.
DR Genevisible; Q8K199; MM.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR InterPro; IPR013892; Cyt_c_biogenesis_Cmc1-like.
DR PANTHER; PTHR22977; PTHR22977; 1.
DR Pfam; PF08583; Cmc1; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..79
FT /note="COX assembly mitochondrial protein 2 homolog"
FT /id="PRO_0000192944"
FT DOMAIN 11..55
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 50..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 14..24
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 37..47
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 14..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 24..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 79 AA; 9419 MW; 27B3EDBAEBB3F54A CRC64;
MHPDLSPHLH TEECNVLINL LKECHKNHNI LKFFGHCNDL DREMRKCLKN EYSERRTRSR
EHGAAMRRRL SDPPEEAGR
