COXS_DICDI
ID COXS_DICDI Reviewed; 55 AA.
AC P20610; Q27561; Q54Z11;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Cytochrome c oxidase subunit 7s;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c oxidase polypeptide VIIs;
GN Name=cxgS; Synonyms=cox7s; ORFNames=DDB_G0277839;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=9049303; DOI=10.1093/emboj/16.4.739;
RA Bisson R., Vettore S., Aratri E., Sandona D.;
RT "Subunit change in cytochrome c oxidase: identification of the oxygen
RT switch in Dictyostelium.";
RL EMBO J. 16:739-749(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
RC STRAIN=AX3;
RX PubMed=7890678; DOI=10.1074/jbc.270.10.5587;
RA Sandona D., Gastaldello S., Rizzuto R., Bisson R.;
RT "Expression of cytochrome c oxidase during growth and development of
RT Dictyostelium.";
RL J. Biol. Chem. 270:5587-5593(1995).
RN [4]
RP PROTEIN SEQUENCE OF 2-35.
RX PubMed=2155132; DOI=10.1016/0014-5793(90)80660-b;
RA Capaldi R.A., Zhang Y.-Z., Rizzuto R., Sandona D., Schiavo G., Bisson R.;
RT "The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium
RT discoideum derive from a common ancestor.";
RL FEBS Lett. 261:158-160(1990).
CC -!- FUNCTION: This protein is one of the nuclear-coded polypeptide chains
CC of cytochrome c oxidase, the terminal oxidase in mitochondrial electron
CC transport.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBUNIT: Slime mold cytochrome c oxidase consists of at least seven
CC different polypeptides species, subunits I, II, III, IV, V, VI, and
CC VIIe/s in order of MW.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC -!- DEVELOPMENTAL STAGE: When cells enter the stationary phase of growth,
CC during the vegetative state, subunit VIIe is replaced by VIIs. The
CC switching depends on the oxygen tension.
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DR EMBL; X99344; CAA67725.1; -; Genomic_DNA.
DR EMBL; AAFI02000023; EAL68092.1; -; Genomic_DNA.
DR EMBL; Z30963; CAA83217.1; -; Genomic_DNA.
DR PIR; B34254; B34254.
DR RefSeq; XP_642041.1; XM_636949.1.
DR AlphaFoldDB; P20610; -.
DR SMR; P20610; -.
DR PaxDb; P20610; -.
DR EnsemblProtists; EAL68092; EAL68092; DDB_G0277839.
DR GeneID; 8621253; -.
DR KEGG; ddi:DDB_G0277839; -.
DR dictyBase; DDB_G0277839; cxgS.
DR HOGENOM; CLU_3072688_0_0_1; -.
DR OMA; MTHALPK; -.
DR PRO; PR:P20610; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR GO; GO:0001666; P:response to hypoxia; IDA:dictyBase.
DR Gene3D; 4.10.93.10; -; 1.
DR InterPro; IPR034884; Cytochrome_c_oxidase_VIc/VIIs.
DR InterPro; IPR037169; Cytochrome_c_oxidase_VIc_sf.
DR Pfam; PF02937; COX6C; 1.
DR SUPFAM; SSF81415; SSF81415; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Translocase;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:2155132"
FT CHAIN 2..55
FT /note="Cytochrome c oxidase subunit 7s"
FT /id="PRO_0000183909"
FT TRANSMEM 13..35
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 55 AA; 6275 MW; 5584DA48AC2E2E20 CRC64;
MTHALPKVVK SQLVQDIGVA LILGSIAGCF FKYGVDKKKQ RERVAFYEKY DKEDL
