COXX1_NATPD
ID COXX1_NATPD Reviewed; 454 AA.
AC Q3IRC9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Protoheme IX farnesyltransferase 1;
DE EC=2.5.1.141;
DE AltName: Full=Heme B farnesyltransferase 1;
DE AltName: Full=Heme O synthase 1;
GN Name=ctaB1; OrderedLocusNames=NP_2446A;
OS Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=348780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC 2260 / Gabara;
RX PubMed=16169924; DOI=10.1101/gr.3952905;
RA Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA Oesterhelt D.;
RT "Living with two extremes: conclusions from the genome sequence of
RT Natronomonas pharaonis.";
RL Genome Res. 15:1336-1343(2005).
CC -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution of
CC the vinyl group on carbon 2 of heme B porphyrin ring with a
CC hydroxyethyl farnesyl side group. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate +
CC Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
CC ChEBI:CHEBI:175763; EC=2.5.1.141;
CC -!- PATHWAY: Porphyrin-containing compound metabolism; heme O biosynthesis;
CC heme O from protoheme: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC according to the Fischer nomenclature. {ECO:0000250}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the UbiA
CC prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR936257; CAI49314.1; -; Genomic_DNA.
DR RefSeq; WP_011322940.1; NC_007426.1.
DR AlphaFoldDB; Q3IRC9; -.
DR SMR; Q3IRC9; -.
DR STRING; 348780.NP_2446A; -.
DR EnsemblBacteria; CAI49314; CAI49314; NP_2446A.
DR GeneID; 3702642; -.
DR KEGG; nph:NP_2446A; -.
DR eggNOG; arCOG00479; Archaea.
DR HOGENOM; CLU_030009_1_1_2; -.
DR OMA; MKPRLMW; -.
DR OrthoDB; 97092at2157; -.
DR UniPathway; UPA00834; UER00712.
DR Proteomes; UP000002698; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd13957; PT_UbiA_Cox10; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR HAMAP; MF_00154; CyoE_CtaB; 1.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR PANTHER; PTHR43448; PTHR43448; 1.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Heme biosynthesis; Membrane; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..454
FT /note="Protoheme IX farnesyltransferase 1"
FT /id="PRO_0000327204"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..186
FT /note="Unknown"
FT REGION 137..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..451
FT /note="Protoheme IX prenyltransferase"
SQ SEQUENCE 454 AA; 46819 MW; 6D7B6240C3F5AC27 CRC64;
MRTTGFSGLL SATVVGVYVL VVVGATAALA DAAAACQGWP LCGGDLSDPS VPVAVLHRGV
AAVVGLLVIA TAVVGWSETT ARVKTTLALA LALYPAQVVL GALVATGSAL ANLHLFVAMA
IFAVLVVGLA WHLEAETGSD DAPESPPELA PPVDEEPAAT EQPALSGLAR AKATARAYFE
LTKPRLMWLL CLVAGAGMVI AGTPTVRTVV FTLGGGVLAI GASGTFNHVL ERDIDRRMER
TSDRPIATHE VPVANALAFG GLLAVASLWA FLSVNLLAAA LGLAAIAFYS VVYTLILKPN
TVQNTVIGGA AGALPALIGY AAVTGTIGIG GLVLAAVIFL WTPAHFYNLA LAYKDDYERG
GFPMMPVVRG ETETRKHIVF YLGATLLGAG ALAAVTDLGW LYAATAVLAA GVFLWAVVEL
HYEQTDRAAF RSFHASNAYL GLVLVAILID SLAV
