COXX2_NATPD
ID COXX2_NATPD Reviewed; 433 AA.
AC Q3INR7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Protoheme IX farnesyltransferase 2;
DE EC=2.5.1.141;
DE AltName: Full=Heme B farnesyltransferase 2;
DE AltName: Full=Heme O synthase 2;
GN Name=ctaB2; OrderedLocusNames=NP_4288A;
OS Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=348780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC 2260 / Gabara;
RX PubMed=16169924; DOI=10.1101/gr.3952905;
RA Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA Oesterhelt D.;
RT "Living with two extremes: conclusions from the genome sequence of
RT Natronomonas pharaonis.";
RL Genome Res. 15:1336-1343(2005).
CC -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution of
CC the vinyl group on carbon 2 of heme B porphyrin ring with a
CC hydroxyethyl farnesyl side group. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate +
CC Fe(II)-heme o; Xref=Rhea:RHEA:28070, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:60344, ChEBI:CHEBI:60530,
CC ChEBI:CHEBI:175763; EC=2.5.1.141;
CC -!- PATHWAY: Porphyrin-containing compound metabolism; heme O biosynthesis;
CC heme O from protoheme: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC according to the Fischer nomenclature. {ECO:0000250}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the UbiA
CC prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
CC {ECO:0000305}.
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DR EMBL; CR936257; CAI50235.1; -; Genomic_DNA.
DR RefSeq; WP_011323851.1; NC_007426.1.
DR AlphaFoldDB; Q3INR7; -.
DR SMR; Q3INR7; -.
DR STRING; 348780.NP_4288A; -.
DR EnsemblBacteria; CAI50235; CAI50235; NP_4288A.
DR GeneID; 3702643; -.
DR KEGG; nph:NP_4288A; -.
DR eggNOG; arCOG00479; Archaea.
DR HOGENOM; CLU_030009_1_1_2; -.
DR OrthoDB; 97092at2157; -.
DR UniPathway; UPA00834; UER00712.
DR Proteomes; UP000002698; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd13957; PT_UbiA_Cox10; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR HAMAP; MF_00154; CyoE_CtaB; 1.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR044878; UbiA_sf.
DR PANTHER; PTHR43448; PTHR43448; 1.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Heme biosynthesis; Membrane; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..433
FT /note="Protoheme IX farnesyltransferase 2"
FT /id="PRO_0000327205"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..164
FT /note="Unknown"
FT REGION 165..430
FT /note="Protoheme IX prenyltransferase"
SQ SEQUENCE 433 AA; 45372 MW; F008932238C33F64 CRC64;
MQRFTGLVTA TTLATYLLVV LGVATELTGG VSPAAVAHYV TAGAVWLLLV AAAALAWRDS
RLPRVKWGVT AAAVAYPAQA AVGMAVLASG GPGQLHLFGG VGVFALLLIT LTWHLDREVE
PRERAAATAF NREGDGDDSV LLYRLPDGLR RYVELTKPRL MWLLCLLALS GMALATVTGA
ALDGVTIAAT LFGGVLAVGA AGTFNHVYER DRDRRMNRTA DRPVATDAVG VGRATAFGVG
LLVVSMAVLV WLVNPLAAAL TAVAVVYYAV VYTVVLKPTT TWNTVIGGGA GALPAVIGWA
AVAGSIGLPA LLLAAVVFCW TPAHFYNLAI AYRDDYARGD YPMLPVVAGV AATRRRILYW
LGATLLVAGA LGAVAGFGPV YALTSAVVGF GFLWTVVVQF RTESDRDAYR SFHASNAYLG
ALLVAILVET MVI
