CP046_HUMAN
ID CP046_HUMAN Reviewed; 395 AA.
AC Q6P387; Q96MA7;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized protein C16orf46;
GN Name=C16orf46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-77.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P387-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P387-2; Sequence=VSP_023435;
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DR EMBL; AK057264; BAB71401.1; -; mRNA.
DR EMBL; BC064143; AAH64143.1; -; mRNA.
DR CCDS; CCDS10932.1; -. [Q6P387-1]
DR CCDS; CCDS42201.1; -. [Q6P387-2]
DR RefSeq; NP_001094343.1; NM_001100873.1. [Q6P387-2]
DR RefSeq; NP_689550.2; NM_152337.2. [Q6P387-1]
DR RefSeq; XP_005255849.1; XM_005255792.2. [Q6P387-2]
DR AlphaFoldDB; Q6P387; -.
DR BioGRID; 125833; 3.
DR IntAct; Q6P387; 3.
DR STRING; 9606.ENSP00000299578; -.
DR iPTMnet; Q6P387; -.
DR PhosphoSitePlus; Q6P387; -.
DR BioMuta; C16orf46; -.
DR DMDM; 147689729; -.
DR MassIVE; Q6P387; -.
DR PaxDb; Q6P387; -.
DR PeptideAtlas; Q6P387; -.
DR PRIDE; Q6P387; -.
DR Antibodypedia; 30436; 47 antibodies from 14 providers.
DR DNASU; 123775; -.
DR Ensembl; ENST00000299578.10; ENSP00000299578.4; ENSG00000166455.14. [Q6P387-1]
DR Ensembl; ENST00000378611.8; ENSP00000367874.4; ENSG00000166455.14. [Q6P387-2]
DR GeneID; 123775; -.
DR KEGG; hsa:123775; -.
DR MANE-Select; ENST00000299578.10; ENSP00000299578.4; NM_152337.3; NP_689550.2.
DR UCSC; uc002fgc.5; human. [Q6P387-1]
DR CTD; 123775; -.
DR DisGeNET; 123775; -.
DR GeneCards; C16orf46; -.
DR HGNC; HGNC:26525; C16orf46.
DR HPA; ENSG00000166455; Tissue enhanced (testis).
DR neXtProt; NX_Q6P387; -.
DR OpenTargets; ENSG00000166455; -.
DR PharmGKB; PA142672254; -.
DR VEuPathDB; HostDB:ENSG00000166455; -.
DR eggNOG; ENOG502SE77; Eukaryota.
DR GeneTree; ENSGT00390000017224; -.
DR HOGENOM; CLU_058645_0_0_1; -.
DR InParanoid; Q6P387; -.
DR OMA; CKEDWAT; -.
DR OrthoDB; 826756at2759; -.
DR PhylomeDB; Q6P387; -.
DR TreeFam; TF338349; -.
DR PathwayCommons; Q6P387; -.
DR SignaLink; Q6P387; -.
DR BioGRID-ORCS; 123775; 8 hits in 1038 CRISPR screens.
DR ChiTaRS; C16orf46; human.
DR GenomeRNAi; 123775; -.
DR Pharos; Q6P387; Tdark.
DR PRO; PR:Q6P387; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6P387; protein.
DR Bgee; ENSG00000166455; Expressed in testis and 95 other tissues.
DR ExpressionAtlas; Q6P387; baseline and differential.
DR Genevisible; Q6P387; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR027836; DUF4529.
DR PANTHER; PTHR36869; PTHR36869; 1.
DR Pfam; PF15032; DUF4529; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..395
FT /note="Uncharacterized protein C16orf46"
FT /id="PRO_0000279429"
FT REGION 115..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 382..395
FT /note="VSRVIIPVSTHRIL -> HRKKKIK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_023435"
FT VARIANT 77
FT /note="T -> S (in dbSNP:rs17855893)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030893"
FT VARIANT 288
FT /note="I -> T (in dbSNP:rs7198494)"
FT /id="VAR_030894"
FT VARIANT 335
FT /note="Y -> H (in dbSNP:rs10459872)"
FT /id="VAR_030895"
FT VARIANT 357
FT /note="K -> E (in dbSNP:rs9930623)"
FT /id="VAR_030896"
FT VARIANT 388
FT /note="P -> S (in dbSNP:rs12929250)"
FT /id="VAR_030897"
FT CONFLICT 217
FT /note="S -> L (in Ref. 1; BAB71401)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 43418 MW; 9B64E3583082DD26 CRC64;
MDLCQKNETD LENAENNEIQ FTEETEPTYT CPDGKSEKNH VYCLLDVSDI TLEQDEKAKE
FIIGTGWEEA VQGWGRTSPA ACIWPRKIPK KARVGEGACS DCLVCVNLSH WSLQTKPPTE
GGPEKDQSSP SQTQAAPQGP STASRAISDI CFPTYFRAEK KSLQIKEFIW CNKDWAIPGT
NRGKASGNPS GGAHRGLSIP GPLTSRALLV LPPLKASLSN ALDVLGKKSK NSFLQSEEKV
LDVEKDGCVA YAYGLKTADG KGEKRASELA KHPMVNDTPS SPSPAAQISL LTDPEQRCLH
WSLLSEKNLA CPPDPSNVRY LAALQLLQKR GVQSYKSKFK AKEPRSPVIT RKHVLPKAKQ
ENRPQMLETK VFPRPVLPSL TVSRVIIPVS THRIL
