CP046_MOUSE
ID CP046_MOUSE Reviewed; 409 AA.
AC Q8BHB7; Q810Q8; Q9D9R4;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized protein C16orf46 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BHB7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BHB7-2; Sequence=VSP_023436, VSP_023437;
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DR EMBL; AK006553; BAB24650.1; -; mRNA.
DR EMBL; AK030075; BAC26769.1; -; mRNA.
DR EMBL; AK031529; BAC27437.1; -; mRNA.
DR EMBL; BC049630; AAH49630.1; -; mRNA.
DR EMBL; BC100501; AAI00502.1; -; mRNA.
DR CCDS; CCDS22695.1; -. [Q8BHB7-1]
DR RefSeq; NP_081379.1; NM_027103.2. [Q8BHB7-1]
DR RefSeq; XP_006531408.1; XM_006531345.2.
DR RefSeq; XP_006531409.1; XM_006531346.3.
DR AlphaFoldDB; Q8BHB7; -.
DR STRING; 10090.ENSMUSP00000070601; -.
DR iPTMnet; Q8BHB7; -.
DR PhosphoSitePlus; Q8BHB7; -.
DR EPD; Q8BHB7; -.
DR PaxDb; Q8BHB7; -.
DR PRIDE; Q8BHB7; -.
DR Antibodypedia; 30436; 47 antibodies from 14 providers.
DR DNASU; 69528; -.
DR Ensembl; ENSMUST00000070577; ENSMUSP00000070601; ENSMUSG00000031847. [Q8BHB7-1]
DR Ensembl; ENSMUST00000213068; ENSMUSP00000148789; ENSMUSG00000031847. [Q8BHB7-1]
DR GeneID; 69528; -.
DR KEGG; mmu:69528; -.
DR UCSC; uc009noq.1; mouse. [Q8BHB7-1]
DR MGI; MGI:1916778; 1700030J22Rik.
DR VEuPathDB; HostDB:ENSMUSG00000031847; -.
DR eggNOG; ENOG502SE77; Eukaryota.
DR GeneTree; ENSGT00390000017224; -.
DR HOGENOM; CLU_058645_0_0_1; -.
DR InParanoid; Q8BHB7; -.
DR OMA; CKEDWAT; -.
DR OrthoDB; 826756at2759; -.
DR PhylomeDB; Q8BHB7; -.
DR TreeFam; TF338349; -.
DR BioGRID-ORCS; 69528; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8BHB7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BHB7; protein.
DR Bgee; ENSMUSG00000031847; Expressed in spermatid and 58 other tissues.
DR ExpressionAtlas; Q8BHB7; baseline and differential.
DR Genevisible; Q8BHB7; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR027836; DUF4529.
DR PANTHER; PTHR36869; PTHR36869; 1.
DR Pfam; PF15032; DUF4529; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..409
FT /note="Uncharacterized protein C16orf46 homolog"
FT /id="PRO_0000279431"
FT REGION 12..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 67..84
FT /note="WEEAVHGWGRTSPTACIW -> SMAGEGPHQLPASGQRRK (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023436"
FT VAR_SEQ 85..409
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023437"
FT CONFLICT 231
FT /note="S -> A (in Ref. 1; BAB24650)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 409 AA; 45038 MW; 360D066F97F85A1D CRC64;
MDVCEESETF LENTENQKIE ATEETAPTLH CPDEKSERSH VCCLLGVSDL TLEEDGRASE
CAISTGWEEA VHGWGRTSPT ACIWSKKKVK RGRAREGTNG GNDCLFCMSL SQGSLEPRSL
LEVGKLEAGA EAEVSTQKSW SSEKNWSGLS QGPGTASREQ SNKLCIPTDV HGEKKSLQLK
EFIWCMEEWP MPETVSSKAG RNPSGSPEQG LSTPDSLAAK ALVVLPPLKS SPHNLDVLSK
KSRNIFWQPE EKVLRVEKDD CMACADGLKG VDGKGEKRHF ELASHVKVTN VLPFPPTAAQ
THLLSAESQR CCLHWSLLPQ KSTVFPPNPS DIHYLATLQV LGQQGKQSCR TRLKTKDTKP
PRTTAKHIIT EAKQQNRPHV LESKVFPKPL LPSLTVSRVV IPVSTHRVL
