CP054_HUMAN
ID CP054_HUMAN Reviewed; 224 AA.
AC Q6UWD8; A6NJR6; Q8NAB0;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transmembrane protein C16orf54;
GN Name=C16orf54; ORFNames=UNQ9389/PRO34280;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP GLYCOSYLATION AT THR-4, STRUCTURE OF CARBOHYDRATES, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=22171320; DOI=10.1074/mcp.m111.013649;
RA Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.;
RT "Human urinary glycoproteomics; attachment site specific analysis of N- and
RT O-linked glycosylations by CID and ECD.";
RL Mol. Cell. Proteomics 11:1-17(2012).
CC -!- INTERACTION:
CC Q6UWD8; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18041102, EBI-12109402;
CC Q6UWD8; P54252: ATXN3; NbExp=3; IntAct=EBI-18041102, EBI-946046;
CC Q6UWD8; O75508: CLDN11; NbExp=3; IntAct=EBI-18041102, EBI-12820543;
CC Q6UWD8; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-18041102, EBI-12033434;
CC Q6UWD8; Q01453: PMP22; NbExp=3; IntAct=EBI-18041102, EBI-2845982;
CC Q6UWD8; Q9NS64: RPRM; NbExp=3; IntAct=EBI-18041102, EBI-1052363;
CC Q6UWD8; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-18041102, EBI-8652744;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- PTM: O-glycosylated with core 1 or possibly core 8 glycans.
CC {ECO:0000269|PubMed:22171320}.
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DR EMBL; AY358833; AAQ89192.1; -; mRNA.
DR EMBL; AK093000; BAC04015.1; -; mRNA.
DR EMBL; CH471238; EAW80012.1; -; Genomic_DNA.
DR EMBL; BC104466; AAI04467.1; -; mRNA.
DR EMBL; BC104467; AAI04468.1; -; mRNA.
DR CCDS; CCDS10652.1; -.
DR RefSeq; NP_787096.2; NM_175900.3.
DR RefSeq; XP_011506896.1; XM_011508594.2.
DR AlphaFoldDB; Q6UWD8; -.
DR BioGRID; 129700; 14.
DR IntAct; Q6UWD8; 12.
DR STRING; 9606.ENSP00000327506; -.
DR GlyConnect; 783; 2 O-Linked glycans (1 site).
DR GlyGen; Q6UWD8; 1 site, 3 O-linked glycans (1 site).
DR iPTMnet; Q6UWD8; -.
DR PhosphoSitePlus; Q6UWD8; -.
DR BioMuta; C16orf54; -.
DR DMDM; 74738078; -.
DR CPTAC; CPTAC-959; -.
DR jPOST; Q6UWD8; -.
DR MassIVE; Q6UWD8; -.
DR PaxDb; Q6UWD8; -.
DR PeptideAtlas; Q6UWD8; -.
DR PRIDE; Q6UWD8; -.
DR ProteomicsDB; 67464; -.
DR Antibodypedia; 54098; 54 antibodies from 13 providers.
DR DNASU; 283897; -.
DR Ensembl; ENST00000329410.4; ENSP00000327506.3; ENSG00000185905.4.
DR GeneID; 283897; -.
DR KEGG; hsa:283897; -.
DR MANE-Select; ENST00000329410.4; ENSP00000327506.3; NM_175900.4; NP_787096.2.
DR UCSC; uc002dtp.3; human.
DR CTD; 283897; -.
DR GeneCards; C16orf54; -.
DR HGNC; HGNC:26649; C16orf54.
DR HPA; ENSG00000185905; Group enriched (bone marrow, lymphoid tissue).
DR neXtProt; NX_Q6UWD8; -.
DR OpenTargets; ENSG00000185905; -.
DR PharmGKB; PA142672261; -.
DR VEuPathDB; HostDB:ENSG00000185905; -.
DR eggNOG; ENOG502SP19; Eukaryota.
DR GeneTree; ENSGT00390000014957; -.
DR HOGENOM; CLU_1224436_0_0_1; -.
DR InParanoid; Q6UWD8; -.
DR OMA; PEWGLQP; -.
DR OrthoDB; 1417661at2759; -.
DR PhylomeDB; Q6UWD8; -.
DR TreeFam; TF337660; -.
DR PathwayCommons; Q6UWD8; -.
DR SignaLink; Q6UWD8; -.
DR BioGRID-ORCS; 283897; 14 hits in 1055 CRISPR screens.
DR Pharos; Q6UWD8; Tdark.
DR PRO; PR:Q6UWD8; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6UWD8; protein.
DR Bgee; ENSG00000185905; Expressed in epithelium of nasopharynx and 119 other tissues.
DR Genevisible; Q6UWD8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031499; DUF4689.
DR PANTHER; PTHR36134; PTHR36134; 1.
DR Pfam; PF15755; DUF4689; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..224
FT /note="Transmembrane protein C16orf54"
FT /id="PRO_0000279442"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 104..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 112
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5BK39"
FT MOD_RES 116
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5BK39"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C708"
FT CARBOHYD 4
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:22171320"
FT CONFLICT 215
FT /note="K -> E (in Ref. 2; BAC04015)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 224 AA; 24360 MW; F3556BF216B1044B CRC64;
MPLTPEPPSG RVEGPPAWEA APWPSLPCGP CIPIMLVLAT LAALFILTTA VLAERLFRRA
LRPDPSHRAP TLVWRPGGEL WIEPMGTARE RSEDWYGSAV PLLTDRAPEP PTQVGTLEAR
ATAPPAPSAP NSAPSNLGPQ TVLEVPARST FWGPQPWEGR PPATGLVSWA EPEQRPEASV
QFGSPQARRQ RPGSPDPEWG LQPRVTLEQI SAFWKREGRT SVGF
