CP054_MOUSE
ID CP054_MOUSE Reviewed; 225 AA.
AC Q8C708; Q6P3A6;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Transmembrane protein C16orf54 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, DBA/2J, and NOD; TISSUE=Kidney, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK052739; BAC35126.1; -; mRNA.
DR EMBL; AK155213; BAE33124.1; -; mRNA.
DR EMBL; AK168260; BAE40208.1; -; mRNA.
DR EMBL; AK169672; BAE41293.1; -; mRNA.
DR EMBL; AK170238; BAE41653.1; -; mRNA.
DR EMBL; BC038694; AAH38694.1; -; mRNA.
DR EMBL; BC064101; AAH64101.1; -; mRNA.
DR CCDS; CCDS21857.1; -.
DR RefSeq; NP_849232.1; NM_178901.3.
DR RefSeq; XP_006507225.1; XM_006507162.3.
DR AlphaFoldDB; Q8C708; -.
DR SMR; Q8C708; -.
DR STRING; 10090.ENSMUSP00000063016; -.
DR iPTMnet; Q8C708; -.
DR PhosphoSitePlus; Q8C708; -.
DR EPD; Q8C708; -.
DR jPOST; Q8C708; -.
DR MaxQB; Q8C708; -.
DR PaxDb; Q8C708; -.
DR PeptideAtlas; Q8C708; -.
DR PRIDE; Q8C708; -.
DR Antibodypedia; 54098; 54 antibodies from 13 providers.
DR DNASU; 101602; -.
DR Ensembl; ENSMUST00000056288; ENSMUSP00000063016; ENSMUSG00000045165.
DR Ensembl; ENSMUST00000206102; ENSMUSP00000146315; ENSMUSG00000045165.
DR GeneID; 101602; -.
DR KEGG; mmu:101602; -.
DR UCSC; uc009juf.1; mouse.
DR MGI; MGI:2141979; AI467606.
DR VEuPathDB; HostDB:ENSMUSG00000045165; -.
DR eggNOG; ENOG502SP19; Eukaryota.
DR GeneTree; ENSGT00390000014957; -.
DR HOGENOM; CLU_1224436_0_0_1; -.
DR InParanoid; Q8C708; -.
DR OMA; PEWGLQP; -.
DR OrthoDB; 1417661at2759; -.
DR PhylomeDB; Q8C708; -.
DR TreeFam; TF337660; -.
DR BioGRID-ORCS; 101602; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8C708; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C708; protein.
DR Bgee; ENSMUSG00000045165; Expressed in peripheral lymph node and 175 other tissues.
DR Genevisible; Q8C708; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031499; DUF4689.
DR PANTHER; PTHR36134; PTHR36134; 1.
DR Pfam; PF15755; DUF4689; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..225
FT /note="Transmembrane protein C16orf54 homolog"
FT /id="PRO_0000279443"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 106..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 113
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5BK39"
FT MOD_RES 117
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5BK39"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT CONFLICT 92
FT /note="R -> L (in Ref. 2; AAH64101)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 24532 MW; B8E8387A88983A2B CRC64;
MPVTPQQPSG HTEGLPEPTA EAAVWVVIPC GPCIPIMLGL ASLTAFFIIT TAVLAERLFR
RPQPDPSQRA PTLVWRPGGE LWIEPTSSAR ERSEDWYGSS MPLLMDRAPG PPTPGGTLEG
RATAPPATSA PYSSLSSLVP QTPPEVPAQS TFWRPQTQEE RPHDTSLVSW VGSEPMPEAG
LQVGSPRPWR PRQGSLEPDW GLQPRVTLEQ ISAFWKREGR TSVGF
