CP074_MOUSE
ID CP074_MOUSE Reviewed; 111 AA.
AC Q8K1L6; E9PUE0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-AUG-2020, sequence version 3.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Uncharacterized protein C16orf74 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-111.
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBUNIT: Interacts (via PxIxIT motif, when phosphorylated on Thr-79)
CC with PPP3CA. {ECO:0000250|UniProtKB:Q96GX8}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH27666.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE43181.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC103360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027666; AAH27666.1; ALT_INIT; mRNA.
DR EMBL; AK004494; BAE43181.1; ALT_INIT; mRNA.
DR CCDS; CCDS52690.1; -.
DR RefSeq; NP_932105.2; NM_197988.1.
DR AlphaFoldDB; Q8K1L6; -.
DR STRING; 10090.ENSMUSP00000119467; -.
DR iPTMnet; Q8K1L6; -.
DR PhosphoSitePlus; Q8K1L6; -.
DR SwissPalm; Q8K1L6; -.
DR PaxDb; Q8K1L6; -.
DR PRIDE; Q8K1L6; -.
DR DNASU; 68918; -.
DR Ensembl; ENSMUST00000123927; ENSMUSP00000119467; ENSMUSG00000043687.
DR GeneID; 68918; -.
DR KEGG; mmu:68918; -.
DR UCSC; uc009nre.1; mouse.
DR MGI; MGI:1916168; 1190005I06Rik.
DR VEuPathDB; HostDB:ENSMUSG00000043687; -.
DR eggNOG; ENOG502SEPB; Eukaryota.
DR GeneTree; ENSGT00390000015933; -.
DR HOGENOM; CLU_172665_0_0_1; -.
DR InParanoid; Q8K1L6; -.
DR TreeFam; TF338382; -.
DR BioGRID-ORCS; 68918; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q8K1L6; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8K1L6; protein.
DR Bgee; ENSMUSG00000043687; Expressed in animal zygote and 74 other tissues.
DR ExpressionAtlas; Q8K1L6; baseline and differential.
DR Genevisible; Q8K1L6; MM.
DR InterPro; IPR027864; DUF4597.
DR PANTHER; PTHR37455; PTHR37455; 1.
DR Pfam; PF15366; DUF4597; 1.
PE 3: Inferred from homology;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..111
FT /note="Uncharacterized protein C16orf74 homolog"
FT /id="PRO_0000264622"
FT REGION 12..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..76
FT /note="Required for interaction with PPP3CA"
FT /evidence="ECO:0000250|UniProtKB:Q96GX8"
FT MOD_RES 79
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96GX8"
FT MOD_RES 81
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96GX8"
SQ SEQUENCE 111 AA; 11870 MW; AFC2A002FBD02252 CRC64;
MTPAAHGCKR VAWCPSRPPA SAPSAPQEAA RRGDAMGLKP SCLKGFKMCV SSSNNNHDEA
PVLNDKHLSV PNIIITPPTP TGMGLSRDSN KQVWMDELGS YQDDGELEPE A
