ID   CP078_HUMAN             Reviewed;         265 AA.
AC   Q8WTQ4;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Uncharacterized protein C16orf78;
GN   Name=C16orf78;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC021181; AAH21181.1; -; mRNA.
DR   EMBL; BC021718; AAH21718.1; -; mRNA.
DR   CCDS; CCDS10738.1; -.
DR   RefSeq; NP_653203.1; NM_144602.3.
DR   AlphaFoldDB; Q8WTQ4; -.
DR   BioGRID; 125845; 4.
DR   IntAct; Q8WTQ4; 3.
DR   STRING; 9606.ENSP00000299191; -.
DR   iPTMnet; Q8WTQ4; -.
DR   PhosphoSitePlus; Q8WTQ4; -.
DR   BioMuta; C16orf78; -.
DR   DMDM; 74730626; -.
DR   MassIVE; Q8WTQ4; -.
DR   PaxDb; Q8WTQ4; -.
DR   PeptideAtlas; Q8WTQ4; -.
DR   PRIDE; Q8WTQ4; -.
DR   ProteomicsDB; 74582; -.
DR   TopDownProteomics; Q8WTQ4; -.
DR   Antibodypedia; 28185; 66 antibodies from 14 providers.
DR   DNASU; 123970; -.
DR   Ensembl; ENST00000299191.4; ENSP00000299191.3; ENSG00000166152.4.
DR   GeneID; 123970; -.
DR   KEGG; hsa:123970; -.
DR   MANE-Select; ENST00000299191.4; ENSP00000299191.3; NM_144602.4; NP_653203.1.
DR   UCSC; uc002efr.4; human.
DR   CTD; 123970; -.
DR   GeneCards; C16orf78; -.
DR   HGNC; HGNC:28479; C16orf78.
DR   HPA; ENSG00000166152; Tissue enriched (testis).
DR   neXtProt; NX_Q8WTQ4; -.
DR   OpenTargets; ENSG00000166152; -.
DR   PharmGKB; PA147358456; -.
DR   VEuPathDB; HostDB:ENSG00000166152; -.
DR   eggNOG; ENOG502SG7H; Eukaryota.
DR   GeneTree; ENSGT00390000014556; -.
DR   HOGENOM; CLU_093507_0_0_1; -.
DR   InParanoid; Q8WTQ4; -.
DR   OMA; PTERKSM; -.
DR   OrthoDB; 1322508at2759; -.
DR   PhylomeDB; Q8WTQ4; -.
DR   TreeFam; TF328628; -.
DR   PathwayCommons; Q8WTQ4; -.
DR   SignaLink; Q8WTQ4; -.
DR   BioGRID-ORCS; 123970; 18 hits in 1036 CRISPR screens.
DR   GenomeRNAi; 123970; -.
DR   Pharos; Q8WTQ4; Tdark.
DR   PRO; PR:Q8WTQ4; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q8WTQ4; protein.
DR   Bgee; ENSG00000166152; Expressed in sperm and 33 other tissues.
DR   Genevisible; Q8WTQ4; HS.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   InterPro; IPR029171; DUF4638.
DR   PANTHER; PTHR35679; PTHR35679; 1.
DR   Pfam; PF15472; DUF4638; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Uncharacterized protein C16orf78"
FT                   /id="PRO_0000296625"
FT   REGION          62..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         152
FT                   /note="R -> Q (in dbSNP:rs16947350)"
FT                   /id="VAR_034632"
SQ   SEQUENCE   265 AA;  30819 MW;  D3B9514F2C4882E7 CRC64;
     MSEQQMDLKD LMPTKRKYMW KTAEDRRMSD LTCVLEWLER RQGKKKQAPE KQKPKVVTVL
     KRNKKKEEKK GKGLMTARGG NRRDTETSQQ ALGKRFRKDA ASYRSLYGVE QKGKHLSMVP
     GSYIKDGPKK SDTDIKDAVD PESTQRPNPF RRQSIVLDPM LQEGTFNSQR ATFIRDWSNK
     MPDMAYERKL KSLMEKSTEP KMETMRMLKP EEVLSCRYLR LSKENIRTLL KLCKDAGMNV
     DIHPHMVEED IDAKKVFTGI PSMAL