CP086_HUMAN
ID CP086_HUMAN Reviewed; 317 AA.
AC Q6ZW13; B5MCW6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Uncharacterized protein C16orf86;
GN Name=C16orf86;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85694.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AK123796; BAC85694.1; ALT_SEQ; mRNA.
DR EMBL; AC010530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW83162.1; -; Genomic_DNA.
DR EMBL; CH471092; EAW83163.1; -; Genomic_DNA.
DR CCDS; CCDS32468.2; -.
DR RefSeq; NP_001013002.2; NM_001012984.2.
DR AlphaFoldDB; Q6ZW13; -.
DR iPTMnet; Q6ZW13; -.
DR PhosphoSitePlus; Q6ZW13; -.
DR BioMuta; C16orf86; -.
DR DMDM; 313104092; -.
DR MassIVE; Q6ZW13; -.
DR MaxQB; Q6ZW13; -.
DR PaxDb; Q6ZW13; -.
DR PeptideAtlas; Q6ZW13; -.
DR PRIDE; Q6ZW13; -.
DR ProteomicsDB; 68452; -.
DR Antibodypedia; 49357; 5 antibodies from 5 providers.
DR DNASU; 388284; -.
DR Ensembl; ENST00000403458.9; ENSP00000384117.3; ENSG00000159761.15.
DR GeneID; 388284; -.
DR KEGG; hsa:388284; -.
DR MANE-Select; ENST00000403458.9; ENSP00000384117.3; NM_001012984.3; NP_001013002.2.
DR UCSC; uc002ety.4; human.
DR CTD; 388284; -.
DR DisGeNET; 388284; -.
DR GeneCards; C16orf86; -.
DR HGNC; HGNC:33755; C16orf86.
DR HPA; ENSG00000159761; Tissue enriched (testis).
DR neXtProt; NX_Q6ZW13; -.
DR OpenTargets; ENSG00000159761; -.
DR PharmGKB; PA162378445; -.
DR VEuPathDB; HostDB:ENSG00000159761; -.
DR eggNOG; ENOG502SVW5; Eukaryota.
DR GeneTree; ENSGT00390000011138; -.
DR HOGENOM; CLU_943194_0_0_1; -.
DR InParanoid; Q6ZW13; -.
DR OMA; VDINKML; -.
DR OrthoDB; 1484877at2759; -.
DR PhylomeDB; Q6ZW13; -.
DR TreeFam; TF337136; -.
DR PathwayCommons; Q6ZW13; -.
DR BioGRID-ORCS; 388284; 55 hits in 1045 CRISPR screens.
DR ChiTaRS; C16orf86; human.
DR GenomeRNAi; 388284; -.
DR Pharos; Q6ZW13; Tdark.
DR PRO; PR:Q6ZW13; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6ZW13; protein.
DR Bgee; ENSG00000159761; Expressed in left testis and 118 other tissues.
DR ExpressionAtlas; Q6ZW13; baseline and differential.
DR Genevisible; Q6ZW13; HS.
DR InterPro; IPR031516; DUF4691.
DR PANTHER; PTHR37867; PTHR37867; 1.
DR Pfam; PF15762; DUF4691; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..317
FT /note="Uncharacterized protein C16orf86"
FT /id="PRO_0000318961"
FT REGION 1..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 33511 MW; 7F42A5AC1B0A16F0 CRC64;
MASAGAERRP GVQEATVVGQ GQLTEEPGSA QTSECPVAGD QFLVPAHEAR GTQSEDQRPA
GAASESELQE EGPKLGEERP KPHAGALEER GPRPVVSIVR PRHGPKRKPV KSLSLPGLRA
HLKAEAELPP KLPLQEEEPE DSQSEPSPSA KQHKKAKKRK SLGAPVLHAV ASMVSAPLET
LRLERKAQRL RPLYQYVNYC NPELNQAGKG DGEAEVEAEA ELAPVPEEGG VEQLQALLPL
AGELGPGLAL PCPSPLVTPT HALAPLGEEA GEEPGGLPSL GVSDHKAEVD KSTQVDIDKM
LSVCTAPLVP PLSPQYK
