CP086_MOUSE
ID CP086_MOUSE Reviewed; 307 AA.
AC Q9D4A5; B7ZN89;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Uncharacterized protein C16orf86 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D4A5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D4A5-2; Sequence=VSP_040246;
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DR EMBL; AK016673; BAB30372.1; -; mRNA.
DR EMBL; CH466525; EDL11312.1; -; Genomic_DNA.
DR EMBL; BC125412; AAI25413.1; -; mRNA.
DR EMBL; BC138007; AAI38008.1; -; mRNA.
DR EMBL; BC145093; AAI45094.1; -; mRNA.
DR CCDS; CCDS52661.1; -. [Q9D4A5-1]
DR CCDS; CCDS90453.1; -. [Q9D4A5-2]
DR RefSeq; NP_081931.1; NM_027655.1. [Q9D4A5-1]
DR RefSeq; XP_006531432.1; XM_006531369.2.
DR AlphaFoldDB; Q9D4A5; -.
DR iPTMnet; Q9D4A5; -.
DR PhosphoSitePlus; Q9D4A5; -.
DR PaxDb; Q9D4A5; -.
DR PRIDE; Q9D4A5; -.
DR Antibodypedia; 49357; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000013302; ENSMUSP00000013302; ENSMUSG00000013158. [Q9D4A5-1]
DR Ensembl; ENSMUST00000211852; ENSMUSP00000148838; ENSMUSG00000013158. [Q9D4A5-2]
DR GeneID; 71046; -.
DR KEGG; mmu:71046; -.
DR UCSC; uc009nea.2; mouse. [Q9D4A5-1]
DR UCSC; uc012gjo.1; mouse. [Q9D4A5-2]
DR MGI; MGI:1918296; 4933405L10Rik.
DR VEuPathDB; HostDB:ENSMUSG00000013158; -.
DR eggNOG; ENOG502SVW5; Eukaryota.
DR GeneTree; ENSGT00390000011138; -.
DR HOGENOM; CLU_943194_0_0_1; -.
DR InParanoid; Q9D4A5; -.
DR OMA; VDINKML; -.
DR OrthoDB; 1271285at2759; -.
DR PhylomeDB; Q9D4A5; -.
DR TreeFam; TF337136; -.
DR BioGRID-ORCS; 71046; 8 hits in 72 CRISPR screens.
DR PRO; PR:Q9D4A5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D4A5; protein.
DR Bgee; ENSMUSG00000013158; Expressed in seminiferous tubule of testis and 8 other tissues.
DR Genevisible; Q9D4A5; MM.
DR InterPro; IPR031516; DUF4691.
DR PANTHER; PTHR37867; PTHR37867; 1.
DR Pfam; PF15762; DUF4691; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..307
FT /note="Uncharacterized protein C16orf86 homolog"
FT /id="PRO_0000402135"
FT REGION 42..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 163..172
FT /note="PFALPWVLAG -> R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040246"
SQ SEQUENCE 307 AA; 32427 MW; 8A069A48CBC0770E CRC64;
MASEGAKRQP ETQNGAAVGL AQVAESLECP GTEECLVPAH ETCRSPGEDK CPVGHSLEPE
LQEEGIKVGE EGLNAGVEAG EERGPKPTSS IVRPAHGPKR KSEVELPPGV LQKKEEPEGS
HSESSLSSKQ HKKAKKRKSG GAPVPPAVAS ASAPAAETLG LEPFALPWVL AGKAQRLRPL
YQYINYCNPE LNQEEDGDRE PEVEPEAELA LVPEEPGVEQ LQLQTLLPVA GELGLGLALP
CPNPLVPLTH NLPPLVEEVG EEPGGLSSLR VSGSLKAEVD KTTQVDIDKM LSVCAAPLVP
PLSPQYK
