CP087_HUMAN
ID CP087_HUMAN Reviewed; 154 AA.
AC Q6PH81; Q63HN9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=UPF0547 protein C16orf87;
GN Name=C16orf87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- INTERACTION:
CC Q6PH81; Q13547: HDAC1; NbExp=4; IntAct=EBI-6598617, EBI-301834;
CC Q6PH81; Q92993: KAT5; NbExp=3; IntAct=EBI-6598617, EBI-399080;
CC Q6PH81; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-6598617, EBI-11742507;
CC Q6PH81; P43365: MAGEA12; NbExp=6; IntAct=EBI-6598617, EBI-749530;
CC Q6PH81; P62937-2: PPIA; NbExp=3; IntAct=EBI-6598617, EBI-25884072;
CC Q6PH81; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-6598617, EBI-9090795;
CC Q6PH81; A7MD48: SRRM4; NbExp=3; IntAct=EBI-6598617, EBI-3867173;
CC Q6PH81; P61981: YWHAG; NbExp=3; IntAct=EBI-6598617, EBI-359832;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PH81-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PH81-2; Sequence=VSP_032670;
CC -!- SIMILARITY: Belongs to the UPF0547 family. {ECO:0000305}.
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DR EMBL; BX647945; CAH56192.1; -; mRNA.
DR EMBL; CH471092; EAW82689.1; -; Genomic_DNA.
DR EMBL; BC056676; AAH56676.1; -; mRNA.
DR CCDS; CCDS10724.1; -. [Q6PH81-1]
DR CCDS; CCDS86522.1; -. [Q6PH81-2]
DR RefSeq; NP_001001436.1; NM_001001436.3. [Q6PH81-1]
DR RefSeq; NP_001335589.1; NM_001348660.1. [Q6PH81-2]
DR AlphaFoldDB; Q6PH81; -.
DR SMR; Q6PH81; -.
DR BioGRID; 132622; 43.
DR IntAct; Q6PH81; 28.
DR MINT; Q6PH81; -.
DR STRING; 9606.ENSP00000285697; -.
DR iPTMnet; Q6PH81; -.
DR PhosphoSitePlus; Q6PH81; -.
DR BioMuta; C16orf87; -.
DR DMDM; 74737667; -.
DR EPD; Q6PH81; -.
DR jPOST; Q6PH81; -.
DR MassIVE; Q6PH81; -.
DR MaxQB; Q6PH81; -.
DR PaxDb; Q6PH81; -.
DR PeptideAtlas; Q6PH81; -.
DR PRIDE; Q6PH81; -.
DR ProteomicsDB; 67121; -. [Q6PH81-1]
DR ProteomicsDB; 67122; -. [Q6PH81-2]
DR Antibodypedia; 52031; 50 antibodies from 12 providers.
DR DNASU; 388272; -.
DR Ensembl; ENST00000285697.9; ENSP00000285697.4; ENSG00000155330.10. [Q6PH81-1]
DR Ensembl; ENST00000394806.6; ENSP00000378285.2; ENSG00000155330.10. [Q6PH81-2]
DR GeneID; 388272; -.
DR KEGG; hsa:388272; -.
DR MANE-Select; ENST00000285697.9; ENSP00000285697.4; NM_001001436.4; NP_001001436.1.
DR UCSC; uc002eek.2; human. [Q6PH81-1]
DR CTD; 388272; -.
DR DisGeNET; 388272; -.
DR GeneCards; C16orf87; -.
DR HGNC; HGNC:33754; C16orf87.
DR HPA; ENSG00000155330; Low tissue specificity.
DR neXtProt; NX_Q6PH81; -.
DR OpenTargets; ENSG00000155330; -.
DR PharmGKB; PA162378458; -.
DR VEuPathDB; HostDB:ENSG00000155330; -.
DR eggNOG; ENOG502RY8J; Eukaryota.
DR GeneTree; ENSGT00390000009505; -.
DR HOGENOM; CLU_2399051_0_0_1; -.
DR InParanoid; Q6PH81; -.
DR OMA; VACKSCT; -.
DR OrthoDB; 1563136at2759; -.
DR PhylomeDB; Q6PH81; -.
DR TreeFam; TF331719; -.
DR PathwayCommons; Q6PH81; -.
DR SignaLink; Q6PH81; -.
DR BioGRID-ORCS; 388272; 16 hits in 1046 CRISPR screens.
DR ChiTaRS; C16orf87; human.
DR GenomeRNAi; 388272; -.
DR Pharos; Q6PH81; Tdark.
DR PRO; PR:Q6PH81; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6PH81; protein.
DR Bgee; ENSG00000155330; Expressed in cortical plate and 163 other tissues.
DR ExpressionAtlas; Q6PH81; baseline and differential.
DR Genevisible; Q6PH81; HS.
DR InterPro; IPR040246; C16orf87-like.
DR InterPro; IPR018886; UPF0547.
DR PANTHER; PTHR31101; PTHR31101; 1.
DR Pfam; PF10571; UPF0547; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..154
FT /note="UPF0547 protein C16orf87"
FT /id="PRO_0000326521"
FT REGION 43..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 104..132
FT /evidence="ECO:0000255"
FT COMPBIAS 43..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..105
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 91
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT VAR_SEQ 55..115
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032670"
SQ SEQUENCE 154 AA; 17799 MW; 016A2E075FF60223 CRC64;
MSATRAKKVK MATKSCPECD QQVPVACKSC PCGYIFISRK LLNAKHSEKS PPSTENKHEA
KRRRTERVRR EKINSTVNKD LENRKRSRSN SHSDHIRRGR GRPKSASAKK HEEEREKQEK
EIDIYANLSD EKAFVFSVAL AEINRKIINQ RLIL
