ID   CP089_DANRE             Reviewed;         351 AA.
AC   A7MCS3;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=UPF0764 protein C16orf89 homolog;
DE   Flags: Precursor;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0764 family. {ECO:0000305}.
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DR   EMBL; BX510989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC152290; AAI52291.1; -; mRNA.
DR   RefSeq; NP_001333209.1; NM_001346280.1.
DR   AlphaFoldDB; A7MCS3; -.
DR   STRING; 7955.ENSDARP00000102869; -.
DR   PaxDb; A7MCS3; -.
DR   Ensembl; ENSDART00000114319; ENSDARP00000102869; ENSDARG00000075345.
DR   GeneID; 566173; -.
DR   KEGG; dre:566173; -.
DR   ZFIN; ZDB-GENE-120215-154; si:ch211-76l23.7.
DR   eggNOG; ENOG502RBYN; Eukaryota.
DR   GeneTree; ENSGT00390000013433; -.
DR   HOGENOM; CLU_051286_0_0_1; -.
DR   InParanoid; A7MCS3; -.
DR   OMA; CTISREC; -.
DR   OrthoDB; 1102348at2759; -.
DR   PhylomeDB; A7MCS3; -.
DR   TreeFam; TF332081; -.
DR   PRO; PR:A7MCS3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000075345; Expressed in brain and 6 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR031751; DUF4735.
DR   PANTHER; PTHR33539; PTHR33539; 1.
DR   Pfam; PF15882; DUF4735; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..351
FT                   /note="UPF0764 protein C16orf89 homolog"
FT                   /id="PRO_0000397602"
FT   CONFLICT        20
FT                   /note="I -> T (in Ref. 2; AAI52291)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   351 AA;  39925 MW;  AB44DF079E77CAC3 CRC64;
     MKSLKMLYPL FMLLVLSSKI DLSNQDVIDN ILMSLSKGIT YFDMQGSNIN LDGVVGYIIL
     QAQLREATRT WPHSDFLSLS QRAAAISMLK RLSKSLSTAA STLQETDPKY FKEFEPILDS
     SFWSLPGEWS STDPSLVYTS VRAMECYDEH MSDKCMTFLL GTWKDNGTPC IVTKTCRDTM
     TQFGCPHYSL SHQLLYFMIG TMKGCSKMLK GDLRLSRVNI TVGHYKRIFC SNMMKSNQDI
     FKNSLTGQMQ DIFIENILLC GLVGFSDFYK LDWLQSILTW QDQEAGCFGK EEDISHIFEE
     FLDAPHKRVK RREKTLTDGC SSHMTGVAVS ALGGFLNFYL SEQDITKRPI I