CP089_HUMAN
ID CP089_HUMAN Reviewed; 402 AA.
AC Q6UX73; B4DUM5; Q8N2I3; Q8N4T1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=UPF0764 protein C16orf89;
DE Flags: Precursor;
GN Name=C16orf89; ORFNames=UNQ904/PRO1925;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT HIS-363.
RC TISSUE=Thyroid;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS ALA-215
RP AND SER-296.
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, SUBUNIT,
RP AND GLYCOSYLATION.
RX PubMed=20578903; DOI=10.1089/thy.2009.0366;
RA Afink G.B., Veenboer G., de Randamie J., Keijser R., Meischl C.,
RA Niessen H., Ris-Stalpers C.;
RT "Initial characterization of C16orf89, a novel thyroid-specific gene.";
RL Thyroid 20:811-821(2010).
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:20578903}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20578903}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UX73-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UX73-2; Sequence=VSP_032600;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in thyroid tissue.
CC {ECO:0000269|PubMed:20578903}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:20578903}.
CC -!- MISCELLANEOUS: [Isoform 2]: Major isoform, represents 80% of
CC transcripts. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0764 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33681.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAQ88847.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC11494.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
CC Sequence=EAW85244.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358483; AAQ88847.1; ALT_INIT; mRNA.
DR EMBL; AK300708; BAG62387.1; -; mRNA.
DR EMBL; AK075242; BAC11494.1; ALT_SEQ; mRNA.
DR EMBL; CH471112; EAW85244.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC033681; AAH33681.1; ALT_INIT; mRNA.
DR CCDS; CCDS42116.2; -. [Q6UX73-1]
DR CCDS; CCDS45404.2; -. [Q6UX73-2]
DR RefSeq; NP_001091984.2; NM_001098514.2. [Q6UX73-2]
DR RefSeq; NP_689672.4; NM_152459.4. [Q6UX73-1]
DR AlphaFoldDB; Q6UX73; -.
DR BioGRID; 126998; 1.
DR IntAct; Q6UX73; 1.
DR STRING; 9606.ENSP00000324672; -.
DR GlyGen; Q6UX73; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6UX73; -.
DR PhosphoSitePlus; Q6UX73; -.
DR BioMuta; C16orf89; -.
DR DMDM; 172046150; -.
DR EPD; Q6UX73; -.
DR jPOST; Q6UX73; -.
DR MassIVE; Q6UX73; -.
DR PaxDb; Q6UX73; -.
DR PeptideAtlas; Q6UX73; -.
DR PRIDE; Q6UX73; -.
DR ProteomicsDB; 67575; -. [Q6UX73-1]
DR ProteomicsDB; 67576; -. [Q6UX73-2]
DR Antibodypedia; 2199; 15 antibodies from 7 providers.
DR DNASU; 146556; -.
DR Ensembl; ENST00000315997.5; ENSP00000324672.5; ENSG00000153446.16. [Q6UX73-1]
DR Ensembl; ENST00000472572.8; ENSP00000420566.2; ENSG00000153446.16. [Q6UX73-2]
DR GeneID; 146556; -.
DR KEGG; hsa:146556; -.
DR MANE-Select; ENST00000472572.8; ENSP00000420566.2; NM_001098514.3; NP_001091984.2. [Q6UX73-2]
DR UCSC; uc002cyk.5; human. [Q6UX73-1]
DR CTD; 146556; -.
DR DisGeNET; 146556; -.
DR GeneCards; C16orf89; -.
DR HGNC; HGNC:28687; C16orf89.
DR HPA; ENSG00000153446; Tissue enhanced (lung, thyroid gland).
DR neXtProt; NX_Q6UX73; -.
DR OpenTargets; ENSG00000153446; -.
DR PharmGKB; PA162378486; -.
DR VEuPathDB; HostDB:ENSG00000153446; -.
DR eggNOG; ENOG502RBYN; Eukaryota.
DR GeneTree; ENSGT00390000013433; -.
DR HOGENOM; CLU_051286_1_0_1; -.
DR InParanoid; Q6UX73; -.
DR OMA; KQFSDGC; -.
DR OrthoDB; 1102348at2759; -.
DR PhylomeDB; Q6UX73; -.
DR PathwayCommons; Q6UX73; -.
DR SignaLink; Q6UX73; -.
DR BioGRID-ORCS; 146556; 12 hits in 1049 CRISPR screens.
DR ChiTaRS; C16orf89; human.
DR GenomeRNAi; 146556; -.
DR Pharos; Q6UX73; Tbio.
DR PRO; PR:Q6UX73; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6UX73; protein.
DR Bgee; ENSG00000153446; Expressed in left lobe of thyroid gland and 143 other tissues.
DR ExpressionAtlas; Q6UX73; baseline and differential.
DR Genevisible; Q6UX73; HS.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR InterPro; IPR031751; DUF4735.
DR PANTHER; PTHR33539; PTHR33539; 1.
DR Pfam; PF15882; DUF4735; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..402
FT /note="UPF0764 protein C16orf89"
FT /id="PRO_0000326202"
FT VAR_SEQ 320..402
FT /note="SRSVAQAGVQWRNLGSLQPLPPGFKQFSCLILPSSWDYRSVPPYLANFYIFL
FT VETGFHHVAHAGLELLISRDPPTSGSQSVGL -> GCSSHNTATAVAALGGFLYILAEY
FT PPANREPHPSTPPPPSSR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_032600"
FT VARIANT 215
FT /note="G -> A (in dbSNP:rs17853191)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057992"
FT VARIANT 296
FT /note="L -> S (in dbSNP:rs1127920)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_040004"
FT VARIANT 363
FT /note="Y -> H (in dbSNP:rs11642955)"
FT /evidence="ECO:0000269|PubMed:16303743"
FT /id="VAR_040005"
FT CONFLICT 77
FT /note="E -> G (in Ref. 2; BAG62387)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="M -> V (in Ref. 2; BAG62387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 45391 MW; 3364A7D02B589AB1 CRC64;
MASLGLLLLL LLTALPPLWS SSLPGLDTAE SKATIADLIL SALERATVFL EQRLPEINLD
GMVGVRVLEE QLKSVREKWA QEPLLQPLSL RVGMLGEKLE AAIQRSLHYL KLSDPKYLRE
FQLTLQPGFW KLPHAWIHTD ASLVYPTFGP QDSFSEERSD VCLVQLLGTG TDSSEPCGLS
DLCRSLMTKP GCSGYCLSHQ LLFFLWARMR GCTQGPLQQS QDYINLFCAN MMDLNRRAEA
IGYAYPTRDI FMENIMFCGM GGFSDFYKLR WLEAILSWQK QQEGCFGEPD AEDEELSKAI
QYQQHFSRRV KRREKQFPDS RSVAQAGVQW RNLGSLQPLP PGFKQFSCLI LPSSWDYRSV
PPYLANFYIF LVETGFHHVA HAGLELLISR DPPTSGSQSV GL
