CP089_MOUSE
ID CP089_MOUSE Reviewed; 385 AA.
AC Q3UST5; B7ZWC6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=UPF0764 protein C16orf89 homolog;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=20578903; DOI=10.1089/thy.2009.0366;
RA Afink G.B., Veenboer G., de Randamie J., Keijser R., Meischl C.,
RA Niessen H., Ris-Stalpers C.;
RT "Initial characterization of C16orf89, a novel thyroid-specific gene.";
RL Thyroid 20:811-821(2010).
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20578903}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in thyroid tissue.
CC {ECO:0000269|PubMed:20578903}.
CC -!- DEVELOPMENTAL STAGE: From embryonic day (E) 17.5 onward in the
CC developing mouse thyroid and lung. {ECO:0000269|PubMed:20578903}.
CC -!- PTM: Glycosylated.
CC -!- SIMILARITY: Belongs to the UPF0764 family. {ECO:0000305}.
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DR EMBL; AK140126; BAE24246.1; -; mRNA.
DR EMBL; CH466521; EDK97282.1; -; Genomic_DNA.
DR EMBL; BC150828; AAI50829.1; -; mRNA.
DR EMBL; BC171979; AAI71979.1; -; mRNA.
DR CCDS; CCDS27934.1; -.
DR RefSeq; NP_001028392.2; NM_001033220.3.
DR AlphaFoldDB; Q3UST5; -.
DR STRING; 10090.ENSMUSP00000058860; -.
DR iPTMnet; Q3UST5; -.
DR PhosphoSitePlus; Q3UST5; -.
DR MaxQB; Q3UST5; -.
DR PaxDb; Q3UST5; -.
DR PRIDE; Q3UST5; -.
DR Antibodypedia; 2199; 15 antibodies from 7 providers.
DR Ensembl; ENSMUST00000050160; ENSMUSP00000058860; ENSMUSG00000051669.
DR GeneID; 239691; -.
DR KEGG; mmu:239691; -.
DR UCSC; uc012aaz.1; mouse.
DR MGI; MGI:2146559; AU021092.
DR VEuPathDB; HostDB:ENSMUSG00000051669; -.
DR eggNOG; ENOG502RBYN; Eukaryota.
DR GeneTree; ENSGT00390000013433; -.
DR HOGENOM; CLU_051286_1_0_1; -.
DR InParanoid; Q3UST5; -.
DR OMA; KQFSDGC; -.
DR OrthoDB; 1102348at2759; -.
DR PhylomeDB; Q3UST5; -.
DR TreeFam; TF332081; -.
DR BioGRID-ORCS; 239691; 0 hits in 70 CRISPR screens.
DR PRO; PR:Q3UST5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q3UST5; protein.
DR Bgee; ENSMUSG00000051669; Expressed in olfactory epithelium and 80 other tissues.
DR Genevisible; Q3UST5; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR InterPro; IPR031751; DUF4735.
DR PANTHER; PTHR33539; PTHR33539; 1.
DR Pfam; PF15882; DUF4735; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..385
FT /note="UPF0764 protein C16orf89 homolog"
FT /id="PRO_0000326203"
FT REGION 344..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 252
FT /note="M -> V (in Ref. 1; BAE24246)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 385 AA; 43079 MW; 735975B85A2BB72F CRC64;
MARLGLLLLL LLALPPHFSS VSWPDTAQGT MANLILTALE KATLFLEDRL PTINLDGVVG
FQVLEVQLRG VQEKWAHKPL LQPLSMRAGQ MANTLSALLQ KSIFYLKQSD PTYLREFQPS
IQPGFWKLPN DWTRTNASLV YPWLEPLDSF SEESSDVCLV QLLGTGTDSS QPCRLSNFCR
TLMTKAGCSG YSLSHQLLFF LWARMQGCTE GLFLQSQHYM DIFCANMMEL NHRAEAVGYA
YPTQDLFMEN IMFCGMAGFS DFYKLRWLEA ILSWQNPQVG CFGRPDTKGE PSEVPHQQGI
LRRVRRREKL FADGCSCHNT ATAVAALGGF LYILAEYHPD NGDAHPEYYP NHGDPYSSSQ
SPASNYQDGA AGPDVQRTGR PLSVS
