ID   CP100_MACFA             Reviewed;         608 AA.
AC   Q4R8V8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Cilia- and flagella-associated protein 100 {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 37 {ECO:0000250|UniProtKB:Q494V2};
GN   Name=CFAP100 {ECO:0000250|UniProtKB:Q494V2};
GN   Synonyms=CCDC37 {ECO:0000250|UniProtKB:Q494V2};
GN   ORFNames=QtsA-11340 {ECO:0000312|EMBL:BAE00463.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in ciliary/flagellar motility by regulating
CC       the assembly and the activity of axonemal inner dynein arm.
CC       {ECO:0000250|UniProtKB:A8I4E9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8I4E9}.
CC   -!- SIMILARITY: Belongs to the CFAP100 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE00463.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE00463.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB168339; BAE00463.1; ALT_SEQ; mRNA.
DR   STRING; 9541.XP_005547965.1; -.
DR   eggNOG; ENOG502QSDI; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0097545; C:axonemal outer doublet; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR   InterPro; IPR025252; DUF4200.
DR   Pfam; PF13863; DUF4200; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..608
FT                   /note="Cilia- and flagella-associated protein 100"
FT                   /id="PRO_0000234488"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          164..196
FT                   /evidence="ECO:0000255"
FT   COILED          230..257
FT                   /evidence="ECO:0000255"
FT   COILED          385..435
FT                   /evidence="ECO:0000255"
FT   COILED          500..575
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  70901 MW;  2096C89FADC1FEFF CRC64;
     MSETLSNIVS KNMTNDKNSL ESMNISSSSS AEENPKKQAK KXKERGPDPS ANPFHLSGDV
     DFFLLRDQER NKALSERQQQ KTMRVHEKMT YSSKVLAKHT SLRRQLQLED KQEDLEARTE
     ADHLRAFRDY NTWKLTLTKE KNVEPENMSG YLKQKRQMFL LQYTLDCKRR EIQRLETLAT
     KEEARLQQAE KSLAKDAALF DEFLRENDCS SVQAMKAAEK ETKAKIEKIL EIRDLTTQIV
     NIKSEISRFE DTLQHYKVYK DFLYKLSPKE WLEEQEKKHL FLKNAKEISE ASKDGSVNST
     PGDKGPGIKG KASSVWAKEG QGTKKPWRFL RLGRSLSYLS SPQQGSQPSE SSGGNSRGSN
     SPIPLTQEDT DSDGEEPQLY FTEPQQLLDV FRELEEQNLS LIQNRQEMEE TLEELSRTLK
     HTQIRMDREV NQLKQWVSTM MMSITKEEDT AAELELKARV FHFGEYKGDQ QDKLLESLNW
     KVLDVYRNCI GTQQEANLGT VQMLTIIEHQ LDELLENLER VPQVKIEQAE RAKEKERRIR
     LREEKLQMQK ILQEERLQRA RARAQAEIKK KRGRTLVCRS QPPVHRIKQE SEHTLMDKEK
     EELLFFFT