CP100_MOUSE
ID CP100_MOUSE Reviewed; 613 AA.
AC Q80VN0; E9PYA2; Q6AXD6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Cilia- and flagella-associated protein 100 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 37 {ECO:0000250|UniProtKB:Q494V2};
GN Name=Cfap100 {ECO:0000312|MGI:MGI:2141635};
GN Synonyms=Ccdc37 {ECO:0000312|MGI:MGI:2141635};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-613.
RC TISSUE=Brain {ECO:0000312|EMBL:AAH79632.1}, and
RC Olfactory epithelium {ECO:0000312|EMBL:AAH47211.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in ciliary/flagellar motility by regulating
CC the assembly and the activity of axonemal inner dynein arm.
CC {ECO:0000250|UniProtKB:A8I4E9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A8I4E9}.
CC -!- SIMILARITY: Belongs to the CFAP100 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47211.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH47211.1; Type=Miscellaneous discrepancy; Note=Intron retention, and aberrant splicing.; Evidence={ECO:0000305};
CC Sequence=AAH79632.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH79632.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AC163346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047211; AAH47211.1; ALT_SEQ; mRNA.
DR EMBL; BC079632; AAH79632.1; ALT_SEQ; mRNA.
DR CCDS; CCDS51849.1; -.
DR RefSeq; NP_776136.2; NM_173775.3.
DR AlphaFoldDB; Q80VN0; -.
DR SMR; Q80VN0; -.
DR BioGRID; 232535; 3.
DR STRING; 10090.ENSMUSP00000126515; -.
DR iPTMnet; Q80VN0; -.
DR PhosphoSitePlus; Q80VN0; -.
DR PaxDb; Q80VN0; -.
DR PRIDE; Q80VN0; -.
DR ProteomicsDB; 283433; -.
DR Antibodypedia; 46637; 148 antibodies from 21 providers.
DR DNASU; 243538; -.
DR Ensembl; ENSMUST00000165673; ENSMUSP00000126515; ENSMUSG00000048794.
DR GeneID; 243538; -.
DR KEGG; mmu:243538; -.
DR UCSC; uc009cxg.2; mouse.
DR UCSC; uc012eoz.1; mouse.
DR CTD; 348807; -.
DR MGI; MGI:2141635; Cfap100.
DR VEuPathDB; HostDB:ENSMUSG00000048794; -.
DR eggNOG; ENOG502QSDI; Eukaryota.
DR GeneTree; ENSGT00940000153110; -.
DR HOGENOM; CLU_026271_0_1_1; -.
DR InParanoid; Q80VN0; -.
DR OMA; YKIYKDF; -.
DR OrthoDB; 1092113at2759; -.
DR PhylomeDB; Q80VN0; -.
DR TreeFam; TF328835; -.
DR BioGRID-ORCS; 243538; 3 hits in 39 CRISPR screens.
DR PRO; PR:Q80VN0; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q80VN0; protein.
DR Bgee; ENSMUSG00000048794; Expressed in spermatid and 64 other tissues.
DR ExpressionAtlas; Q80VN0; baseline and differential.
DR GO; GO:0097545; C:axonemal outer doublet; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR InterPro; IPR025252; DUF4200.
DR Pfam; PF13863; DUF4200; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..613
FT /note="Cilia- and flagella-associated protein 100"
FT /id="PRO_0000234489"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..198
FT /evidence="ECO:0000255"
FT COILED 233..260
FT /evidence="ECO:0000255"
FT COILED 396..435
FT /evidence="ECO:0000255"
FT COILED 504..580
FT /evidence="ECO:0000255"
FT CONFLICT 535
FT /note="E -> V (in Ref. 2; AAH79632)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 72033 MW; DB57C2D27F68E6B3 CRC64;
MAFKARSSRF SVKMVEDTGG SQDLINNSFS SFIEEKSKES KKNKGNVTIS DRSSNPFHIS
RDMDYFLLRE QEQNQAIAER EQKKILRVHQ KMTYASKVSA KHTSLRRELQ LEDEMEQQLL
NAEAKEMNCF RENNDWKLAM TRERKREPET LNDYMEKRRS MFLLQYALAM KRNEIQRLEM
LATREENRLE RAEKFLEKDA SLFDEFLREN DRNSVQAMRM AEKETKIKTE KIVEIRELTA
QITSIKSEIS KFEDTLKHYK IYKEFLYKLS PKEWLDEQQE KHLAFKRAKE SSELTRNNST
AILFGDKGSG SKSKTAFLWK EVPGLKKVTK TGRLVKALSS SIQSLPQVGQ LTQLSPHSEL
DSRLSSTMFP SQDDTDSDGE ELALYFTEPQ QLLDVFTKLE EENLSLIQNT QEMEETLDEL
NVTLKNTQIR MDKEVNLLKQ WIASMMISIS KEEESAAELE LKARVFHFGE YQGDQQDTML
ESLNHKVLEV YRKCVGMQQE ANLGTVQMLT VVERQLDELL ENLERVPQVK IEQAEKAKER
ERRMRLREEK AMMQKQLQEE RLQRARARAQ AKIKKKRGRK LISRSHPPVI KVKEVREQTL
INKDKEEMLF FFT
