ID   CP123_MYCTU             Reviewed;         402 AA.
AC   P9WPP5; L0T7F5; P63707; P77902;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Putative cytochrome P450 123;
DE            EC=1.14.-.-;
GN   Name=cyp123; OrderedLocusNames=Rv0766c; ORFNames=MTCY369.11c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43513.1; -; Genomic_DNA.
DR   PIR; A70707; A70707.
DR   RefSeq; NP_215280.1; NC_000962.3.
DR   RefSeq; WP_003403911.1; NZ_NVQJ01000035.1.
DR   AlphaFoldDB; P9WPP5; -.
DR   SMR; P9WPP5; -.
DR   STRING; 83332.Rv0766c; -.
DR   PaxDb; P9WPP5; -.
DR   DNASU; 888834; -.
DR   GeneID; 888834; -.
DR   KEGG; mtu:Rv0766c; -.
DR   TubercuList; Rv0766c; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; WGHRNPD; -.
DR   PhylomeDB; P9WPP5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0036199; F:cholest-4-en-3-one 26-monooxygenase activity; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0008395; F:steroid hydroxylase activity; IBA:GO_Central.
DR   GO; GO:0006707; P:cholesterol catabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..402
FT                   /note="Putative cytochrome P450 123"
FT                   /id="PRO_0000052276"
FT   BINDING         350
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   402 AA;  45421 MW;  76AD843019361798 CRC64;
     MTVRVGDPEL VLDPYDYDFH EDPYPYYRRL RDEAPLYRNE ERNFWAVSRH HDVLQGFRDS
     TALSNAYGVS LDPSSRTSEA YRVMSMLAMD DPAHLRMRTL VSKGFTPRRI RELEPQVLEL
     ARIHLDSALQ TESFDFVAEF AGKLPMDVIS ELIGVPDTDR ARIRALADAV LHREDGVADV
     PPPAMAASIE LMRYYADLIA EFRRRPANNL TSALLAAELD GDRLSDQEIM AFLFLMVIAG
     NETTTKLLAN AVYWAAHHPG QLARVFADHS RIPMWVEETL RYDTSSQILA RTVAHDLTLY
     DTTIPEGEVL LLLPGSANRD DRVFDDPDDY RIGREIGCKL VSFGSGAHFC LGAHLARMEA
     RVALGALLRR IRNYEVDDDN VVRVHSSNVR GFAHLPISVQ AR