ID   CP126_MYCTU             Reviewed;         414 AA.
AC   P9WPN9; L0T4P8; P63711; P77903;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Putative cytochrome P450 126;
DE            EC=1.14.-.-;
GN   Name=cyp126; OrderedLocusNames=Rv0778; ORFNames=MTCY369.22;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP43525.1; -; Genomic_DNA.
DR   PIR; E70708; E70708.
DR   RefSeq; NP_215292.1; NC_000962.3.
DR   RefSeq; WP_003898584.1; NZ_NVQJ01000035.1.
DR   PDB; 5LI6; X-ray; 1.95 A; A/B=1-414.
DR   PDB; 5LI7; X-ray; 1.58 A; A/B=1-414.
DR   PDB; 5LI8; X-ray; 1.83 A; A=1-414.
DR   PDB; 5LIE; X-ray; 1.80 A; A/B=1-414.
DR   PDBsum; 5LI6; -.
DR   PDBsum; 5LI7; -.
DR   PDBsum; 5LI8; -.
DR   PDBsum; 5LIE; -.
DR   AlphaFoldDB; P9WPN9; -.
DR   SMR; P9WPN9; -.
DR   STRING; 83332.Rv0778; -.
DR   PaxDb; P9WPN9; -.
DR   DNASU; 888913; -.
DR   GeneID; 888913; -.
DR   KEGG; mtu:Rv0778; -.
DR   TubercuList; Rv0778; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; ESERHWL; -.
DR   PhylomeDB; P9WPN9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0036199; F:cholest-4-en-3-one 26-monooxygenase activity; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0008395; F:steroid hydroxylase activity; IBA:GO_Central.
DR   GO; GO:0006707; P:cholesterol catabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..414
FT                   /note="Putative cytochrome P450 126"
FT                   /id="PRO_0000052282"
FT   BINDING         363
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   414 AA;  45954 MW;  2CCCBE0250818E3F CRC64;
     MTTAAGLSGI DLTDLDNFAD GFPHHLFAIH RREAPVYWHR PTEHTPDGEG FWSVATYAET
     LEVLRDPVTY SSVTGGQRRF GGTVLQDLPV AGQVLNMMDD PRHTRIRRLV SSGLTPRMIR
     RVEDDLRRRA RGLLDGVEPG APFDFVVEIA AELPMQMICI LLGVPETDRH WLFEAVEPGF
     DFRGSRRATM PRLNVEDAGS RLYTYALELI AGKRAEPADD MLSVVANATI DDPDAPALSD
     AELYLFFHLL FSAGAETTRN SIAGGLLALA ENPDQLQTLR SDFELLPTAI EEIVRWTSPS
     PSKRRTASRA VSLGGQPIEA GQKVVVWEGS ANRDPSVFDR ADEFDITRKP NPHLGFGQGV
     HYCLGANLAR LELRVLFEEL LSRFGSVRVV EPAEWTRSNR HTGIRHLVVE LRGG