ID   CP128_MYCBO             Reviewed;         489 AA.
AC   P63714; A0A1R3Y0Q6; Q59572; X2BKL8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Putative cytochrome P450 128;
DE            EC=1.14.-.-;
GN   Name=cyp128; OrderedLocusNames=BQ2027_MB2291C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00902.1; -; Genomic_DNA.
DR   RefSeq; NP_855940.1; NC_002945.3.
DR   RefSeq; WP_003411663.1; NC_002945.4.
DR   AlphaFoldDB; P63714; -.
DR   SMR; P63714; -.
DR   EnsemblBacteria; SIU00902; SIU00902; BQ2027_MB2291C.
DR   PATRIC; fig|233413.5.peg.2516; -.
DR   OMA; GRVHYNP; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Heme; Iron; Membrane; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..489
FT                   /note="Putative cytochrome P450 128"
FT                   /id="PRO_0000052283"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         435
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   489 AA;  53313 MW;  633F233CEF03AD7A CRC64;
     MTATQSPPEP APDRVRLAGC PLAGTPDVGL TAQDATTALG VPTRRRASSG GIPVATSMWR
     DAQTVRTYGP AVAKALALRV AGKARSRLTG RHCRKFMQLT DFDPFDPAIA ADPYPHYREL
     LAGERVQYNP KRDVYILSRY ADVREAARNH DTLSSARGVT FSRGWLPFLP TSDPPAHTRM
     RKQLAPGMAR GALETWRPMV DQLARELVGG LLTQTPADVV STVAAPMPMR AITSVLGVDG
     PDEAAFCRLS NQAVRITDVA LSASGLISLV QGFAGFRRLR ALFTHRRDNG LLRECTVLGK
     LATHAEQGRL SDDELFFFAV LLLVAGYEST AHMISTLFLT LADYPDQLTL LAQQPDLIPS
     AIEEHLRFIS PIQNICRTTR VDYSVGQAVI PAGSLVLLAW GAANRDPRQY EDPDVFRADR
     NPVGHLAFGS GIHLCPGTQL ARMEGQAILR EIVANIDRIE VVEPPTWTTN ANLRGLTRLR
     VAVTPRVAP