ID   CP137_MYCTU             Reviewed;         476 AA.
AC   P9WPM5; L0TDI2; O69653;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Putative cytochrome P450 137;
DE            EC=1.14.-.-;
GN   Name=cyp137; OrderedLocusNames=Rv3685c; ORFNames=MTV025.033c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46509.1; -; Genomic_DNA.
DR   PIR; F70791; F70791.
DR   RefSeq; NP_218202.1; NC_000962.3.
DR   RefSeq; WP_003419754.1; NZ_NVQJ01000028.1.
DR   AlphaFoldDB; P9WPM5; -.
DR   SMR; P9WPM5; -.
DR   STRING; 83332.Rv3685c; -.
DR   PaxDb; P9WPM5; -.
DR   DNASU; 885625; -.
DR   GeneID; 885625; -.
DR   KEGG; mtu:Rv3685c; -.
DR   TubercuList; Rv3685c; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; EMGWPMV; -.
DR   PhylomeDB; P9WPM5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..476
FT                   /note="Putative cytochrome P450 137"
FT                   /id="PRO_0000052296"
FT   BINDING         422
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   476 AA;  52266 MW;  4FF0DBC89D8D0548 CRC64;
     MVLRSLASPA ALTDPKRCAS VVGVAAFAVR REHAPDALGG PPGLPAPRGF RAAFAAAYAV
     AYLAGGERRM LRLIRRYGPI MTMPILSLGD VAIVSDSALA KEVFTAPTDV LLGGEGVGPA
     AAIYGSGSMF VQEEPEHLRR RKLLTPPLHG AALDRYVPII ENSTRAAMHT WPVDRPFAML
     TVARSLMLDV IVKVIFGVDD PEEVRRLGRP FERLLNLGVS EQLTVRYALR RLGALRVWPA
     RARANTEIDD VVMALIAQRR ADPRLGERHD VLSLLVSARG ESGEQLSDSE IRDDLITLVL
     AGHETTATTL AWAFDLLLHH PDALRRVRAE AVGGGEAFTT AVINETLRVR PPAPLTARVA
     AQPLTIGGYR VEAGTRIVVH IIAINRSAEV YEHPHEFRPE RFLGTRPQTY AWVPFGGGVK
     RCLGANFSMR ELITVLHVLL REGEFTAVDD EPERIVRRSI MLVPRRGTRV RFRPAR