CP138_MYCBO
ID CP138_MYCBO Reviewed; 441 AA.
AC P63718; A0A1R3XV13; P96813; X2BE52;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Putative cytochrome P450 138;
DE EC=1.14.-.-;
GN Name=cyp138; OrderedLocusNames=BQ2027_MB0141;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; LT708304; SIT98575.1; -; Genomic_DNA.
DR RefSeq; NP_853807.1; NC_002945.3.
DR RefSeq; WP_003400938.1; NC_002945.4.
DR AlphaFoldDB; P63718; -.
DR SMR; P63718; -.
DR GeneID; 45424102; -.
DR PATRIC; fig|233413.5.peg.162; -.
DR OMA; SDQRHPY; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT CHAIN 1..441
FT /note="Putative cytochrome P450 138"
FT /id="PRO_0000052297"
FT BINDING 388
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 441 AA; 49261 MW; 0E433656428A64EB CRC64;
MSEVVTAAPA PPVVRLPPAV RGPKLFQGLA FVVSRRRLLG RFVRRYGKAF TANILMYGRV
VVVADPQLAR QVFTSSPEEL GNIQPNLSRM FGSGSVFALD GDDHRRRRRL LAPPFHGKSM
KNYETIIEEE TLRETANWPQ GQAFATLPSM MHITLNAILR AIFGAGGSEL DELRRLIPPW
VTLGSRLAAL PKPKRDYGRL SPWGRLAEWR RQYDTVIDKL IEAERADPNF ADRTDVLALM
LRSTYDDGSI MSRKDIGDEL LTLLAAGHET TAATLGWAFE RLSRHPDVLA ALVEEVDNGG
HELRQAAILE VQRARTVIDF AARRVNPPVY QLGEWVIPRG YSIIINIAQI HGDPDVFPQP
DRFDPQRYIG SKPSPFAWIP FGGGTRRCVG AAFANMEMDV VLRTVLRHFT LETTTAAGER
SHGRGVAFTP KDGGRVVMRR R