ID   CP138_MYCTU             Reviewed;         441 AA.
AC   P9WPM3; L0T5T2; P63717; P96813;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Putative cytochrome P450 138;
DE            EC=1.14.-.-;
GN   Name=cyp138; OrderedLocusNames=Rv0136; ORFNames=MTCI5.10;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP42861.1; -; Genomic_DNA.
DR   PIR; C70616; C70616.
DR   RefSeq; NP_214650.1; NC_000962.3.
DR   RefSeq; WP_003400938.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WPM3; -.
DR   SMR; P9WPM3; -.
DR   STRING; 83332.Rv0136; -.
DR   PaxDb; P9WPM3; -.
DR   DNASU; 886868; -.
DR   GeneID; 45424102; -.
DR   GeneID; 886868; -.
DR   KEGG; mtu:Rv0136; -.
DR   TubercuList; Rv0136; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; SDQRHPY; -.
DR   PhylomeDB; P9WPM3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..441
FT                   /note="Putative cytochrome P450 138"
FT                   /id="PRO_0000052298"
FT   BINDING         388
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   441 AA;  49261 MW;  0E433656428A64EB CRC64;
     MSEVVTAAPA PPVVRLPPAV RGPKLFQGLA FVVSRRRLLG RFVRRYGKAF TANILMYGRV
     VVVADPQLAR QVFTSSPEEL GNIQPNLSRM FGSGSVFALD GDDHRRRRRL LAPPFHGKSM
     KNYETIIEEE TLRETANWPQ GQAFATLPSM MHITLNAILR AIFGAGGSEL DELRRLIPPW
     VTLGSRLAAL PKPKRDYGRL SPWGRLAEWR RQYDTVIDKL IEAERADPNF ADRTDVLALM
     LRSTYDDGSI MSRKDIGDEL LTLLAAGHET TAATLGWAFE RLSRHPDVLA ALVEEVDNGG
     HELRQAAILE VQRARTVIDF AARRVNPPVY QLGEWVIPRG YSIIINIAQI HGDPDVFPQP
     DRFDPQRYIG SKPSPFAWIP FGGGTRRCVG AAFANMEMDV VLRTVLRHFT LETTTAAGER
     SHGRGVAFTP KDGGRVVMRR R