ID   CP139_MYCTU             Reviewed;         430 AA.
AC   P9WPM1; D0EW72; F2GKM3; O86330; P63719;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Putative cytochrome P450 139;
DE            EC=1.14.-.-;
GN   Name=cyp139; OrderedLocusNames=Rv1666c; ORFNames=MTV047.02c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Vasilevskaya A.V., Alyapkina Y.S., Usanov S.A.;
RT   "Polymorphism of cytochrome P450 of drug resistant form of Mycobacterium
RT   tuberculosis.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; GQ900520; ACX47919.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP44431.1; -; Genomic_DNA.
DR   PIR; D70985; D70985.
DR   RefSeq; NP_216182.1; NC_000962.3.
DR   RefSeq; WP_003901231.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WPM1; -.
DR   SMR; P9WPM1; -.
DR   STRING; 83332.Rv1666c; -.
DR   PaxDb; P9WPM1; -.
DR   DNASU; 885528; -.
DR   GeneID; 45425635; -.
DR   GeneID; 885528; -.
DR   KEGG; mtu:Rv1666c; -.
DR   PATRIC; fig|83332.111.peg.1852; -.
DR   TubercuList; Rv1666c; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; KFVFANA; -.
DR   PhylomeDB; P9WPM1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00465; EP450IV.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..430
FT                   /note="Putative cytochrome P450 139"
FT                   /id="PRO_0000052300"
FT   BINDING         372
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   430 AA;  47865 MW;  DCBA4CF08FAD1A94 CRC64;
     MRYPLGEALL ALYRWRGPLI NAGVGGHGYT YLLGAEANRF VFANADAFSW SQTFESLVPV
     DGPTALIVSD GADHRRRRSV VAPGLRHHHV QRYVATMVSN IDTVIDGWQP GQRLDIYQEL
     RSAVRRSTAE SLFGQRLAVH SDFLGEQLQP LLDLTRRPPQ VMRLQQRVNS PGWRRAMAAR
     KRIDDLIDAQ IADARTAPRP DDHMLTTLIS GCSEEGTTLS DNEIRDSIVS LITAGYETTS
     GALAWAIYAL LTVPGTWESA ASEVARVLGG RVPAADDLSA LTYLNGVVHE TLRLYSPGVI
     SARRVLRDLW FDGHRIRAGR LLIFSAYVTH RLPEIWPEPT EFRPLRWDPN AADYRKPAPH
     EFIPFSGGLH RCIGAVMATT EMTVILARLV ARAMLQLPAQ RTHRIRAANF AALRPWPGLT
     VEIRKSAPAQ