ID   CP140_MYCBO             Reviewed;         438 AA.
AC   P63722; A0A1R3XZM3; O08464; X2BJA3;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Putative cytochrome P450 140;
DE            EC=1.14.-.-;
GN   Name=cyp140; OrderedLocusNames=BQ2027_MB1912C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00516.1; -; Genomic_DNA.
DR   RefSeq; NP_855564.1; NC_002945.3.
DR   RefSeq; WP_003409406.1; NC_002945.4.
DR   AlphaFoldDB; P63722; -.
DR   SMR; P63722; -.
DR   EnsemblBacteria; SIU00516; SIU00516; BQ2027_MB1912C.
DR   GeneID; 45425853; -.
DR   PATRIC; fig|233413.5.peg.2095; -.
DR   OMA; RPELWPN; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN           1..438
FT                   /note="Putative cytochrome P450 140"
FT                   /id="PRO_0000052301"
FT   BINDING         381
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   438 AA;  48872 MW;  0463B3EECF358744 CRC64;
     MKDKLHWLAM HGVIRGIAAI GIRRGDLQAR LIADPAVATD PVPFYDEVRS HGALVRNRAN
     YLTVDHRLAH DLLRSDDFRV VSFGENLPPP LRWLERRTRG DQLHPLREPS LLAVEPPDHT
     RYRKTVSAVF TSRAVSALRD LVEQTAINLL DRFAEQPGIV DVVGRYCSQL PIVVISEILG
     VPEHDRPRVL EFGELAAPSL DIGIPWRQYL RVQQGIRGFD CWLEGHLQQL RHAPGDDLMS
     QLIQIAESGD NETQLDETEL RAIAGLVLVA GFETTVNLLG NGIRMLLDTP EHLATLRQHP
     ELWPNTVEEI LRLDSPVQLT ARVACRDVEV AGVRIKRGEV VVIYLAAANR DPAVFPDPHR
     FDIERPNAGR HLAFSTGRHF CLGAALARAE GEVGLRTFFD RFPDVRAAGA GSRRDTRVLR
     GWSTLPVTLG PARSMVSP