ID   CP140_MYCTU             Reviewed;         438 AA.
AC   P9WPL9; L0T9I7; O08464; P63721;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Putative cytochrome P450 140;
DE            EC=1.14.-.-;
GN   Name=cyp140; OrderedLocusNames=Rv1880c; ORFNames=MTCY180.38;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44646.1; -; Genomic_DNA.
DR   PIR; E70515; E70515.
DR   RefSeq; NP_216396.3; NC_000962.3.
DR   RefSeq; WP_003409406.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WPL9; -.
DR   SMR; P9WPL9; -.
DR   STRING; 83332.Rv1880c; -.
DR   PaxDb; P9WPL9; -.
DR   DNASU; 885758; -.
DR   GeneID; 45425853; -.
DR   GeneID; 885758; -.
DR   KEGG; mtu:Rv1880c; -.
DR   TubercuList; Rv1880c; -.
DR   eggNOG; COG2124; Bacteria.
DR   OMA; RPELWPN; -.
DR   PhylomeDB; P9WPL9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..438
FT                   /note="Putative cytochrome P450 140"
FT                   /id="PRO_0000052302"
FT   BINDING         381
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   438 AA;  48872 MW;  0463B3EECF358744 CRC64;
     MKDKLHWLAM HGVIRGIAAI GIRRGDLQAR LIADPAVATD PVPFYDEVRS HGALVRNRAN
     YLTVDHRLAH DLLRSDDFRV VSFGENLPPP LRWLERRTRG DQLHPLREPS LLAVEPPDHT
     RYRKTVSAVF TSRAVSALRD LVEQTAINLL DRFAEQPGIV DVVGRYCSQL PIVVISEILG
     VPEHDRPRVL EFGELAAPSL DIGIPWRQYL RVQQGIRGFD CWLEGHLQQL RHAPGDDLMS
     QLIQIAESGD NETQLDETEL RAIAGLVLVA GFETTVNLLG NGIRMLLDTP EHLATLRQHP
     ELWPNTVEEI LRLDSPVQLT ARVACRDVEV AGVRIKRGEV VVIYLAAANR DPAVFPDPHR
     FDIERPNAGR HLAFSTGRHF CLGAALARAE GEVGLRTFFD RFPDVRAAGA GSRRDTRVLR
     GWSTLPVTLG PARSMVSP