ID   CP141_BOVIN             Reviewed;         101 AA.
AC   Q32L75;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Cilia- and flagella-associated protein 141 {ECO:0000250|UniProtKB:Q5VU69};
GN   Name=CFAP141 {ECO:0000250|UniProtKB:Q5VU69};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
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DR   EMBL; BC109726; AAI09727.1; -; mRNA.
DR   RefSeq; NP_001033115.1; NM_001038026.2.
DR   PDB; 7RRO; EM; 3.40 A; C=1-101.
DR   PDBsum; 7RRO; -.
DR   AlphaFoldDB; Q32L75; -.
DR   SMR; Q32L75; -.
DR   STRING; 9913.ENSBTAP00000044427; -.
DR   PaxDb; Q32L75; -.
DR   Ensembl; ENSBTAT00000047205; ENSBTAP00000044427; ENSBTAG00000033220.
DR   GeneID; 504348; -.
DR   KEGG; bta:504348; -.
DR   CTD; 388701; -.
DR   VEuPathDB; HostDB:ENSBTAG00000033220; -.
DR   VGNC; VGNC:52709; CFAP141.
DR   eggNOG; ENOG502SF03; Eukaryota.
DR   GeneTree; ENSGT00510000048901; -.
DR   HOGENOM; CLU_2290739_0_0_1; -.
DR   InParanoid; Q32L75; -.
DR   OMA; KKMVNRW; -.
DR   OrthoDB; 1553237at2759; -.
DR   TreeFam; TF341125; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000033220; Expressed in semen and 94 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   InterPro; IPR029375; CFAP141.
DR   Pfam; PF15104; DUF4558; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..101
FT                   /note="Cilia- and flagella-associated protein 141"
FT                   /id="PRO_0000270965"
SQ   SEQUENCE   101 AA;  12339 MW;  E4AE7327E00262CD CRC64;
     MSMEKMGKVE EHFQRALELK KMVHRWRNSH THCLWQITLS QRRNPYAILR MQDTMVQELA
     LANKQLLMVR QAALHQLFEK EHQQYQQELN EKGKAFYMER L