ID   CP141_HUMAN             Reviewed;         101 AA.
AC   Q5VU69; A1L4E3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Cilia- and flagella-associated protein 141 {ECO:0000312|HGNC:HGNC:32305};
GN   Name=CFAP141 {ECO:0000312|HGNC:HGNC:32305};
GN   Synonyms=C1orf189 {ECO:0000312|HGNC:HGNC:32305};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000250|UniProtKB:Q32L75}.
CC   -!- INTERACTION:
CC       Q5VU69; Q9Y5B8: NME7; NbExp=10; IntAct=EBI-10247920, EBI-744782;
CC       Q5VU69; Q9H7Z7: PTGES2; NbExp=3; IntAct=EBI-10247920, EBI-681645;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q32L75}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471121; EAW53228.1; -; Genomic_DNA.
DR   EMBL; BC127710; AAI27711.1; -; mRNA.
DR   EMBL; BC130509; AAI30510.1; -; mRNA.
DR   CCDS; CCDS30876.1; -.
DR   RefSeq; NP_001010979.1; NM_001010979.2.
DR   AlphaFoldDB; Q5VU69; -.
DR   SMR; Q5VU69; -.
DR   BioGRID; 132817; 54.
DR   IntAct; Q5VU69; 2.
DR   STRING; 9606.ENSP00000357511; -.
DR   PhosphoSitePlus; Q5VU69; -.
DR   BioMuta; C1orf189; -.
DR   DMDM; 74747059; -.
DR   MassIVE; Q5VU69; -.
DR   PaxDb; Q5VU69; -.
DR   PeptideAtlas; Q5VU69; -.
DR   PRIDE; Q5VU69; -.
DR   ProteomicsDB; 65393; -.
DR   Antibodypedia; 62988; 65 antibodies from 10 providers.
DR   DNASU; 388701; -.
DR   Ensembl; ENST00000368525.4; ENSP00000357511.3; ENSG00000163263.7.
DR   GeneID; 388701; -.
DR   KEGG; hsa:388701; -.
DR   MANE-Select; ENST00000368525.4; ENSP00000357511.3; NM_001010979.3; NP_001010979.1.
DR   UCSC; uc001fee.3; human.
DR   CTD; 388701; -.
DR   GeneCards; C1orf189; -.
DR   HGNC; HGNC:32305; CFAP141.
DR   HPA; ENSG00000163263; Group enriched (fallopian tube, testis).
DR   neXtProt; NX_Q5VU69; -.
DR   VEuPathDB; HostDB:ENSG00000163263; -.
DR   eggNOG; ENOG502SF03; Eukaryota.
DR   GeneTree; ENSGT00510000048901; -.
DR   HOGENOM; CLU_2290739_0_0_1; -.
DR   InParanoid; Q5VU69; -.
DR   OMA; KKMVNRW; -.
DR   OrthoDB; 1553237at2759; -.
DR   PhylomeDB; Q5VU69; -.
DR   TreeFam; TF341125; -.
DR   PathwayCommons; Q5VU69; -.
DR   SignaLink; Q5VU69; -.
DR   BioGRID-ORCS; 388701; 9 hits in 1046 CRISPR screens.
DR   GenomeRNAi; 388701; -.
DR   Pharos; Q5VU69; Tdark.
DR   PRO; PR:Q5VU69; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5VU69; protein.
DR   Bgee; ENSG00000163263; Expressed in right uterine tube and 87 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   InterPro; IPR029375; CFAP141.
DR   Pfam; PF15104; DUF4558; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..101
FT                   /note="Cilia- and flagella-associated protein 141"
FT                   /id="PRO_0000270966"
SQ   SEQUENCE   101 AA;  12131 MW;  7FA55630DCDEC78B CRC64;
     MSVEKMTKVE ESFQKAMGLK KTVDRWRNSH THCLWQMALG QRRNPYATLR MQDTMVQELA
     LAKKQLLMVR QAALHQLFEK EHQQYQQELN QMGKAFYVER F