CP141_MOUSE
ID CP141_MOUSE Reviewed; 101 AA.
AC Q9D9D9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Cilia- and flagella-associated protein 141 {ECO:0000250|UniProtKB:Q5VU69};
GN Name=Cfap141 {ECO:0000250|UniProtKB:Q5VU69};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:Q32L75}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q32L75}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH48560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB24846.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK007060; BAB24846.1; ALT_INIT; mRNA.
DR EMBL; BC048560; AAH48560.1; ALT_INIT; mRNA.
DR CCDS; CCDS50968.2; -.
DR RefSeq; NP_082843.1; NM_028567.1.
DR AlphaFoldDB; Q9D9D9; -.
DR SMR; Q9D9D9; -.
DR PhosphoSitePlus; Q9D9D9; -.
DR MaxQB; Q9D9D9; -.
DR PaxDb; Q9D9D9; -.
DR PRIDE; Q9D9D9; -.
DR Antibodypedia; 62988; 65 antibodies from 10 providers.
DR DNASU; 73545; -.
DR Ensembl; ENSMUST00000238911; ENSMUSP00000158884; ENSMUSG00000118506.
DR GeneID; 73545; -.
DR KEGG; mmu:73545; -.
DR UCSC; uc008qbe.2; mouse.
DR CTD; 388701; -.
DR MGI; MGI:1920795; 1700094D03Rik.
DR VEuPathDB; HostDB:ENSMUSG00000118506; -.
DR GeneTree; ENSGT00510000048901; -.
DR InParanoid; Q9D9D9; -.
DR OrthoDB; 1553237at2759; -.
DR PhylomeDB; Q9D9D9; -.
DR TreeFam; TF341125; -.
DR BioGRID-ORCS; 73545; 2 hits in 25 CRISPR screens.
DR PRO; PR:Q9D9D9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D9D9; protein.
DR Bgee; ENSMUSG00000118506; Expressed in spermatid and 59 other tissues.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR029375; CFAP141.
DR Pfam; PF15104; DUF4558; 1.
PE 3: Inferred from homology;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..101
FT /note="Cilia- and flagella-associated protein 141"
FT /id="PRO_0000270967"
SQ SEQUENCE 101 AA; 12258 MW; D8240E158E36E7A7 CRC64;
MSAEKMTKLE ENLQRAVALK KTVDRWRNFH IHCMWQTTLD QRRNLFAALR MKDTKEQELA
LSNKQLLVVR QAALHELFEK EYQQYQQELN QMGKAFYEER L
