ID   CP1A1_ORYLA             Reviewed;         521 AA.
AC   Q6JZS3;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Cytochrome P450 1A1;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIA1;
GN   Name=cyp1a1; Synonyms=cyp1a;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15178024; DOI=10.1016/j.marenvres.2004.03.006;
RA   Kim I.-C., Kim Y.J., Yoon Y.-D., Kawamura S., Lee Y.-S., Lee J.-S.;
RT   "Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite fish
RT   Rivulus marmoratus and the Japanese medaka Oryzias latipes.";
RL   Mar. Environ. Res. 58:125-129(2004).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       They oxidize a variety of structurally unrelated compounds, including
CC       steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Microsome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AY233000; AAP68769.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6JZS3; -.
DR   SMR; Q6JZS3; -.
DR   STRING; 8090.ENSORLP00000018073; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   InParanoid; Q6JZS3; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01683; EP450ICYP1A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..521
FT                   /note="Cytochrome P450 1A1"
FT                   /id="PRO_0000051644"
FT   BINDING         229
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         463
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   521 AA;  58887 MW;  E36092B9E9957AF3 CRC64;
     MALMVLPFIG PLSVLEGLIA LTTVCVVYLL LKHFNKEIPG GLRQLPGPTP LPIIGNLLKL
     GSKPYLSLTE MSKRFGDVFQ IQIGMRPVVV LSGNETVRQA LIKQGDDFSG RPDLYSFQFI
     NDGKSLAFST DQAGVWRARR KLAYSALRSF SSLEGSNAEY SCMLEEHICK ETEHLVKEIE
     KVMKTEGKFD PYRYIVVSVA NVICGMCFGR RYDHHDQELV GLVNLSEDFV QVTGSGNPAD
     FIPALRYLPS KAMKKFVEIN NRFQSFVQKI VNEHSATYDK DNIRDITDSL IDHCEDRKLD
     ENSNIQMSDE KVVGIVNDLF GAGFDTISTA LSWAVGYLVA YPDIEKGLFE EIKENIGLNR
     NPTISDRSNL PLTDAFILEI FRHSSFLPFT IPHCTTRDTS LNGYYIPKDT CVFINQWQIN
     HDPKLWQDPS SFNPDRFLSE DGSEVNRLDG EKVMVFGLGK RRCIGEVIAR NEVFLFLAIM
     IQKLCFEEMP GEPLDMTPEY GLTMKHKRCN VRASLRLKDG C