ID   CP1A2_CHICK             Reviewed;         258 AA.
AC   Q01741;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Cytochrome P450 1A2;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIA2;
DE   Flags: Fragment;
GN   Name=CYP1A2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=2025265; DOI=10.1016/0006-291x(91)91654-u;
RA   Murti J.R., Adiga P.R., Padmanaban G.;
RT   "Estradiol-17 beta induces polyaromatic hydrocarbon-inducible cytochrome P-
RT   450 in chicken liver.";
RL   Biochem. Biophys. Res. Commun. 175:928-935(1991).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       In liver microsomes, this enzyme is involved in an NADPH-dependent
CC       electron transport pathway. It oxidizes a variety of structurally
CC       unrelated compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- INDUCTION: By 3-methylcholanthrene (3MC) and estradiol-17-beta.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M64537; AAA62735.1; -; mRNA.
DR   PIR; JT0575; JT0575.
DR   AlphaFoldDB; Q01741; -.
DR   SMR; Q01741; -.
DR   VEuPathDB; HostDB:geneid_396051; -.
DR   InParanoid; Q01741; -.
DR   PhylomeDB; Q01741; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           <1..258
FT                   /note="Cytochrome P450 1A2"
FT                   /id="PRO_0000051657"
FT   NON_TER         1
SQ   SEQUENCE   258 AA;  29914 MW;  D20F5EAC4DEE52DB CRC64;
     KFLQIAVEEH YQSFDKNNIR DVTDSLWRSK KTKPRGAADP NEKIINLVND IFGAGFDTVT
     TALSWSLMYL VTQPHSQKKI QESELDTAIG RERRSWLSER SMLPYKEAFI LETVPTWQFV
     PFTIPHSTTR DTTLNGFHIP KECCVFVNQW QVNHEAELWE DPFVFRTERF LTDDSTAIDK
     TLSEKVMGKQ VGLAWKSALG TRQWEVSFYL STLTPNWSSA PGGESKKDRV RPIYGLSMKH
     KRCEHFQVKK RFSMKSSN