CP1_APLCA
ID CP1_APLCA Reviewed; 209 AA.
AC Q10998;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Cerebral peptide 1;
DE Short=CP1;
DE AltName: Full=Connecting peptide 3;
DE Short=CP3;
DE Contains:
DE RecName: Full=APGW-amide;
DE Contains:
DE RecName: Full=Cerebral peptide 1;
DE Short=CP1;
DE Contains:
DE RecName: Full=C-terminal peptide;
DE Short=CTP;
DE Flags: Precursor;
OS Aplysia californica (California sea hare).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC Aplysiidae; Aplysia.
OX NCBI_TaxID=6500;
RN [1]
RP PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, AMIDATION AT
RP TRP-49; TRP-83; TRP-105; TRP-128; TRP-135; TRP-142; TRP-149; TRP-156 AND
RP TRP-163, AND MASS SPECTROMETRY.
RC TISSUE=Neuron;
RX PubMed=10959975; DOI=10.1021/ac000260z;
RA Li L., Romanova E.V., Rubakhin S.S., Alexeeva V., Weiss K.R., Vilim F.S.,
RA Sweedler J.V.;
RT "Peptide profiling of cells with multiple gene products: combining
RT immunochemistry and MALDI mass spectrometry with on-plate
RT microextraction.";
RL Anal. Chem. 72:3867-3874(2000).
RN [2]
RP PROTEIN SEQUENCE OF 87-99, AND TISSUE SPECIFICITY.
RC TISSUE=Ganglion;
RX PubMed=8844763; DOI=10.1016/0196-9781(96)00081-2;
RA Phares G.A., Lloyd P.E.;
RT "Purification, primary structure, and neuronal localization of cerebral
RT peptide 1 from Aplysia.";
RL Peptides 17:753-761(1996).
CC -!- FUNCTION: May function as a peptide transmitter.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Cerebral peptide 1 is expressed in the cerebral,
CC pedal and buccal ganglia and B1 and B2 neurons. APGW-amide is expressed
CC in buccal ganglia and several neurons. {ECO:0000269|PubMed:10959975,
CC ECO:0000269|PubMed:8844763}.
CC -!- MASS SPECTROMETRY: [Cerebral peptide 1]: Mass=1313.6; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10959975};
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DR RefSeq; NP_001191561.1; NM_001204632.1.
DR AlphaFoldDB; Q10998; -.
DR GeneID; 100533336; -.
DR OrthoDB; 1344573at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..43
FT /note="Connecting peptide 1"
FT /id="PRO_0000311887"
FT PEPTIDE 46..49
FT /note="APGW-amide"
FT /id="PRO_0000311888"
FT PROPEP 53..77
FT /note="Connecting peptide 2"
FT /id="PRO_0000311889"
FT PEPTIDE 80..83
FT /note="APGW-amide"
FT /id="PRO_0000311890"
FT PEPTIDE 87..99
FT /note="Cerebral peptide 1"
FT /id="PRO_0000044127"
FT PEPTIDE 102..105
FT /note="APGW-amide"
FT /id="PRO_0000311891"
FT PROPEP 109..122
FT /note="Connecting peptide 4"
FT /id="PRO_0000311892"
FT PEPTIDE 125..128
FT /note="APGW-amide"
FT /id="PRO_0000311893"
FT PEPTIDE 132..135
FT /note="APGW-amide"
FT /id="PRO_0000311894"
FT PEPTIDE 139..142
FT /note="APGW-amide"
FT /id="PRO_0000311895"
FT PEPTIDE 146..149
FT /note="APGW-amide"
FT /id="PRO_0000311896"
FT PEPTIDE 153..156
FT /note="APGW-amide"
FT /id="PRO_0000311897"
FT PEPTIDE 160..163
FT /note="APGW-amide"
FT /id="PRO_0000311898"
FT PROPEP 167..191
FT /note="Connecting peptide 5"
FT /id="PRO_0000311899"
FT PEPTIDE 194..209
FT /note="C-terminal peptide"
FT /id="PRO_0000311900"
FT REGION 21..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 83
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 105
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 128
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 135
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 142
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 149
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 156
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT MOD_RES 163
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:10959975"
FT DISULFID 172..197
SQ SEQUENCE 209 AA; 22521 MW; 16F0C08A051CB924 CRC64;
MLLAKISVVV LLLAIDGTSS SESTDNVVLS SSPDSQKAAT SRHKRAPGWG KRSSLNDEDL
FADSDSAQEL LDSVAALKRA PGWGKRFSGL MSEGSSLEAK RAPGWGKRGQ EIDVDEDGSE
QEKRAPGWGK RAPGWGKRAP GWGKRAPGWG KRAPGWGKRA PGWGKRSGGD YCETLEKMVD
AYIYKAVEVD SRRLADCGSG EGTNEPFRK
