ID   CP20A_BOVIN             Reviewed;         462 AA.
AC   Q5E980;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Cytochrome P450 20A1;
DE            EC=1.14.-.-;
GN   Name=CYP20A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT021040; AAX09057.1; -; mRNA.
DR   RefSeq; NP_001015644.1; NM_001015644.1.
DR   AlphaFoldDB; Q5E980; -.
DR   SMR; Q5E980; -.
DR   STRING; 9913.ENSBTAP00000001132; -.
DR   PaxDb; Q5E980; -.
DR   Ensembl; ENSBTAT00000001132; ENSBTAP00000001132; ENSBTAG00000000851.
DR   GeneID; 532945; -.
DR   KEGG; bta:532945; -.
DR   CTD; 57404; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000851; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   GeneTree; ENSGT00500000044939; -.
DR   HOGENOM; CLU_050960_1_0_1; -.
DR   InParanoid; Q5E980; -.
DR   OMA; YFQVWSE; -.
DR   OrthoDB; 1038194at2759; -.
DR   TreeFam; TF105089; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000000851; Expressed in corpus epididymis and 109 other tissues.
DR   ExpressionAtlas; Q5E980; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..462
FT                   /note="Cytochrome P450 20A1"
FT                   /id="PRO_0000318094"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         409
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   462 AA;  52674 MW;  21DAF116A4948405 CRC64;
     MLDFAIFAVT FLLALVGAVL YLYPASRQAA GIPGITPTEE KDGNLPDIVN SGSLHEFLVN
     LHERYGPVVS FWFGRRLVVS LGTVDVLKQH INPNKTLDPF ETMLKSLLRY QSDSGNVSEN
     HMRKKLYENG VTNCLRSNFA LLIKLSEELL DKWLSYPESQ HVPLCQHMLG FAMKSVTQMV
     MGSTFEDEQE VIRFQKNHGT VWSEIGKGFL DGSLDKSTTR KKQYEDALMQ LESILKKIIK
     ERKGRNFSQH IFIDSLVQGN LNDQQILEDT MIFSLASCMI TAKLCTWAVC FLTTYEEIQK
     KLYEEIDQVL GKGPITSEKI EELRYCRQVL CETVRTAKLT PVSARLQDIE GKIDKFIIPR
     ETLVLYALGV VLQDPGTWSS PYKFDPERFD DESVMKTFSL LGFSGTRECP ELRFAYMVTA
     VLLSVLLRRL HLLSVEGQVI ETKYELVTSS KEEAWITVSK RY