ID   CP20A_RAT               Reviewed;         462 AA.
AC   Q6P7D4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Cytochrome P450 20A1;
DE            EC=1.14.-.-;
GN   Name=Cyp20a1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; BC061716; AAH61716.1; -; mRNA.
DR   RefSeq; NP_955433.1; NM_199401.1.
DR   AlphaFoldDB; Q6P7D4; -.
DR   SMR; Q6P7D4; -.
DR   STRING; 10116.ENSRNOP00000023796; -.
DR   iPTMnet; Q6P7D4; -.
DR   PhosphoSitePlus; Q6P7D4; -.
DR   jPOST; Q6P7D4; -.
DR   PaxDb; Q6P7D4; -.
DR   PRIDE; Q6P7D4; -.
DR   GeneID; 316435; -.
DR   KEGG; rno:316435; -.
DR   CTD; 57404; -.
DR   RGD; 735221; Cyp20a1.
DR   eggNOG; KOG0157; Eukaryota.
DR   InParanoid; Q6P7D4; -.
DR   OrthoDB; 1038194at2759; -.
DR   PhylomeDB; Q6P7D4; -.
DR   PRO; PR:Q6P7D4; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..462
FT                   /note="Cytochrome P450 20A1"
FT                   /id="PRO_0000318097"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         409
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   462 AA;  51998 MW;  D09CD1F59B323EEE CRC64;
     MLDFAIFAVT FLLALVGAVL YLYPASRQAS GIPGLTPTEE KDGNLPDIVN SGSLHEFLVN
     LHGRYGPVVS FWFGRRLVVS LGTADALKQH FNPNKTLDPF ETMLKSLLGY RSGAGSGSED
     HVRRRLYGDA VTAALQSNFP LLLKLSEELL DKWLSYPETQ HIPLSQHMLG FALKFVTRMV
     LGDTFEGEQE VIRFQKIHGT VWSEIGKGFL DGSLDKNTTR KNQYQEALMQ LEAILKKIIK
     ERKGGDFSQH TFIDSLVQRN LNEQQILEDS VVFSLAGCIV TARLCTWAIH FLTTAEEVQK
     KLHKEVDHVL GKGPITSEKI EQLRYCQQVL CETVRTAKLT PVSAQLQDIE GKVGPFIIPK
     ETLVLYALGV VLQDASTWPS PHKFDPDRFA DEPVMKVFSS LGFSGTWECP ELRFAYVVTT
     VLVSVLLKKL HLLAVDRQVF EMKYELVTSC REETWITVSE RH